Instabilities of proteins: theoretical aspects, degradation products and methods for their detection
Recombinant DNA technology has led to a significant increase in the number of peptide and protein based pharmaceuticals, giving a new approach to combat poorly controlled diseases. This particular development has been reached in the last two decades. However, proteins are highly susceptible of phy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
2005-12-01
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| Series: | Makedonsko Farmacevtski Bilten |
| Online Access: | http://bulletin.mfd.org.mk/volumes/Volume%2051/51_001.pdf |
| Summary: | Recombinant DNA technology has led to a significant increase in the number of peptide and protein based pharmaceuticals,
giving a new approach to combat poorly controlled diseases. This particular development has been reached in the last two
decades. However, proteins are highly susceptible of physical and chemical degradation resulting in a decrease or complete loss
of biological activities. Reasons for their physical and chemical instabilities and the methods for their examination, become a
challenge for the pharmaceutical scientists for successful development of stabile protein - based pharmaceuticals.
The stability of protein - based pharmaceuticals is significant in terms of their pharmaceutical quality and biological activity.
In addition, a right choice of suitable analytical methods is needed in order to detect an early formation of degradation products
or modified forms. |
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| ISSN: | 1409-8695 1857-8969 |