Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.

Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.

DNA methylation is an important epigenetic modification and is frequently altered in cancer. Convert of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC) by ten-eleven translocation (TET) family enzymes plays important biological functions in embryonic stem cells, development, aging and dis...

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Bibliographic Details
Main Authors: Chungang Liu, Limei Liu, Xuejiao Chen, Junjie Shen, Juanjuan Shan, Yanmin Xu, Zhi Yang, Lin Wu, Feng Xia, Ping Bie, Youhong Cui, Xiu-wu Bian, Cheng Qian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3650038?pdf=render

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http://europepmc.org/articles/PMC3650038?pdf=render

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