Development of a Novel BAFF Responsive Cell Line Suitable for Detecting Bioactive BAFF and Neutralizing Antibodies against BAFF-Pathway Inhibiting Therapeutics

Development of a Novel BAFF Responsive Cell Line Suitable for Detecting Bioactive BAFF and Neutralizing Antibodies against BAFF-Pathway Inhibiting Therapeutics

BAFF has a critical role in B-cell survival, maturation and function, which makes its pathway a prime therapeutic target for various autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis and Sjögren’s syndrome. A cell-based assay that measures the functional activity...

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Bibliographic Details
Main Authors:	Jenny Hu, Yanbin Yu, Hong Han, Francesca Civoli, Yao Zhuang, John Thomas, Steve Swanson, Shuqian Jing, Shalini Gupta
Format:	Article
Language:	English
Published:	MDPI AG 2014-02-01
Series:	Cells
Subjects:	hybrid receptor neutralizing antibody detection BAFF response serum matrix transfection COS-1 cell line
Online Access:	http://www.mdpi.com/2073-4409/3/1/79

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