Assessment of illness-related indicators in peripheral blood and skin lesion tissue of patients with vitiligo after NB-UVB, triamcinolone acetonide and vitiligo granules triple treatment

• Main Authors: Wei-Liang Wang, Yan Chen, Feng-Bin Liu, Yuan-Zuo Huang, Ju-Zhen Lin, Guan-Biao Lyu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-04-01
• Series: Journal of Hainan Medical University
• Subjects: Vitiligo; Narrow band ultraviolet B; Vitiligo granules; T lymphocytes; Immune function
• Online Access: http://www.hnykdxxb.com/PDF/201608/29.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the changes of illness-related indicators in peripheral blood and skin lesion tissue of patients with vitiligo after NB-UVB, triamcinolone acetonide and vitiligo granules triple treatment. Methods: Patients with vitiligo were selected as research subjects and randomly divided into two groups, observation group received NB-UVB, triamcinolone acetonide and vitiligo granules triple treatment, control group received combined therapy of NB-UVB and triamcinolone acetonide, and then the contents of lymphocyte subsets and cytokines in peripheral blood as well as the expression of illness-related molecules in skin lesion tissue were detected. Results: After treatment, the percentage of CD3+ CD28+, CD3+CD4+CD28+, CD3+CD8+CD28+ and Th17cells as well as the contents of IL-17 and IL-6 in peripheral blood of observation group were significantly lower than those of control group, and the percentage of CD3+ CTLA4+, CD3+CD4+ CTLA4+, CD3+CD8+ CTLA4+ and Treg cells as well as the contents of IL-10 and TGF-β were significantly higher than those of control group; the expression levels of Nrf-2, SCF, c-kit and InnVit in skin lesion tissue of observation group were higher than those of control group, and CLEC2B expression level was lower than that of control group. Conclusion: NB-UVB, triamcinolone acetonide and vitiligo granules triple treatment can more effectively regulate immune function and expression of illness-related molecules in skin lesion tissue of patients with vitiligo.