ELEVATION OF SERUM C-REACTIVE PROTEIN AND S100 PROTEINS FOR SYSTEMIC INFLAMMATION IN AUTISTIC CHILDREN

• Main Author: Vijendra SINGH
• Format: Article
• Language: English
• Published: Faculty of Philosophy, Institute of Special Education and Rehabilitation 2005-12-01
• Series: Journal of Special Education and Rehabilitation
• Subjects: Autism; C-reactive protein; S100 proteins; Inflammation; Acute-phase response; Autoimmunity; Brain disorders
• Online Access: http://jser.fzf.ukim.edu.mk/pdf/3-42005/13-SING%20VIENGRA-Iskustva%20i%20novini%20od%20svetot.pdf

The pathogenesis of autism, a neurological disorder severely affecting young children, may involve inflammation and autoimmunity. In this report, the distribution of acute-phase C-reactive protein (CRP) and S100 proteins was examined in normal and autistic children. Their serum levels were measured by enzyme-linked immunosorbent assay (ELISA). Autistic children were found to have significantly higher than normal levels of CRP (p=0.005) and S100 proteins (p=0.03). The existence of elevated levels of CRP and S100 proteins in autistic children is an excellent sign of systemic inflammation that may contribute to the neuropathology of this brain disorder.