Association of MiR-21 expression and hypertension: A Meta-analysis

• Main Authors: Li-Jun Zhu, Yan Chen, Ying-Shui Yao
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2021-01-01
• Series: Journal of Hainan Medical University
• Subjects: mir-21; hypertension; meta-analysis
• Online Access: http://www.hnykdxxb.com/PDF/202101/08.pdf

Objective: To systematically evaluate the relationship between the miR-21 level in peripheral blood and hypertension. Methods: A systematic literature searching of CNKI, Wanfang and VIP databases, PubMed, Web of Science and EMBASE by keywords was performed up to the end of November 2020. All statistical analysis was performed using the state16.0 software. Results: A total of 9 studies including 577 hypertension patients and 344 healthy controls were selected. The combined effect SMD was 1.53 (95% CI: 0.58-2.47, P = 0.002). It is suggested that the level of miR-21 in peripheral blood of patients with hypertension is higher than that of controls. In subgroup analysis, the level of miR-21 in peripheral blood mononuclear cells (PBMC) in hypertensives was higher than that in controls (SMD = 3.49, 95% CI: 1.24-5.74), and the difference was statistically significant (P = 0.002). But the association was not found in plasma (P = 0.375). No publication bias was found in our study by Begg's funnel plot and Egger's test. Conclusion: The increased level of miR-21 in peripheral blood, especially in PBMC, is a risk factor for hypertension. Limited by the number of included studies, the conclusion still needs to be verified by more high-quality studies.