Association of MiR-21 expression and hypertension: A Meta-analysis
Objective: To systematically evaluate the relationship between the miR-21 level in peripheral blood and hypertension. Methods: A systematic literature searching of CNKI, Wanfang and VIP databases, PubMed, Web of Science and EMBASE by keywords was performed up to the end of November 2020. All stat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2021-01-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/202101/08.pdf |
| Summary: | Objective: To systematically evaluate the relationship between the miR-21 level in peripheral
blood and hypertension. Methods: A systematic literature searching of CNKI, Wanfang and
VIP databases, PubMed, Web of Science and EMBASE by keywords was performed up to the
end of November 2020. All statistical analysis was performed using the state16.0 software.
Results: A total of 9 studies including 577 hypertension patients and 344 healthy controls were
selected. The combined effect SMD was 1.53 (95% CI: 0.58-2.47, P = 0.002). It is suggested
that the level of miR-21 in peripheral blood of patients with hypertension is higher than that
of controls. In subgroup analysis, the level of miR-21 in peripheral blood mononuclear cells
(PBMC) in hypertensives was higher than that in controls (SMD = 3.49, 95% CI: 1.24-5.74),
and the difference was statistically significant (P = 0.002). But the association was not found
in plasma (P = 0.375). No publication bias was found in our study by Begg's funnel plot
and Egger's test. Conclusion: The increased level of miR-21 in peripheral blood, especially
in PBMC, is a risk factor for hypertension. Limited by the number of included studies, the
conclusion still needs to be verified by more high-quality studies. |
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| ISSN: | 1007-1237 1007-1237 |