Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes.

INTRODUCTION:Ca2+ release from sarcoplasmic reticulum (SR) is known to contribute to automaticity via the cytoplasmic Na+-Ca2+ exchanger (NCX). Mitochondria participate in Ca2+ cycling. We studied the role of mitochondrial Ca2+ flux in ventricular spontaneous electrical activity. METHODS:Spontaneous...

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Bibliographic Details
Main Authors: An Xie, Anyu Zhou, Hong Liu, Guangbin Shi, Man Liu, Kenneth R Boheler, Samuel C Dudley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6042741?pdf=render