An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water

An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water

Various antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with a variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using Zirconia Sulfuric Acid (ZrSA) nanoparticle, as a catalyst in the pre...

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Main Authors: Ahmad Nakhaei, Abolghasem Davoodnia, Sepideh Yadegarian
Format: Article
Language:English
Published: Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR 2018-06-01
Series:Iranian Journal of Chemistry & Chemical Engineering
Subjects:
fluoroquinolone derivatives
antibacterial
fast and green synthesis
zirconia sulfuric acid (zrsa)
ordinary or magnetized water
Online Access:http://www.ijcce.ac.ir/article_27405_c5f4d9ea1aa8e3af6b5f5a1397d45823.pdf
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spelling doaj-dc516505c64c45d59bd95154920f51122020-11-25T03:47:00ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering 1021-99861021-99862018-06-01373334227405An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of WaterAhmad Nakhaei0Abolghasem Davoodnia1Sepideh Yadegarian2Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRANDepartment of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRANYoung Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, I.R. IRANVarious antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with a variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using Zirconia Sulfuric Acid (ZrSA) nanoparticle, as a catalyst in the presence of ordinary or magnetized water upon reflux condition. The results showed that ZrSA exhibited high catalytic activity towards the synthesis of fluoroquinolone derivatives in two forms of water. However, the magnetized water showed better results. Furthermore, the catalyst was recyclable and could be reused at least three times without any discernible loss in its catalytic activity. Overall, this new catalytic method for the synthesis of fluoroquinolone derivatives provides rapid access to the desired compounds in refluxing water following a simple work‐up procedure and avoids the use of harmful organic solvents. This method, therefore, represents a significant improvement over the methods currently available for the synthesis of fluoroquinolone derivatives.http://www.ijcce.ac.ir/article_27405_c5f4d9ea1aa8e3af6b5f5a1397d45823.pdffluoroquinolone derivativesantibacterialfast and green synthesiszirconia sulfuric acid (zrsa)ordinary or magnetized water
collection DOAJ
language English
format Article
sources DOAJ
author Ahmad Nakhaei
Abolghasem Davoodnia
Sepideh Yadegarian
spellingShingle Ahmad Nakhaei
Abolghasem Davoodnia
Sepideh Yadegarian
An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
Iranian Journal of Chemistry & Chemical Engineering
fluoroquinolone derivatives
antibacterial
fast and green synthesis
zirconia sulfuric acid (zrsa)
ordinary or magnetized water
author_facet Ahmad Nakhaei
Abolghasem Davoodnia
Sepideh Yadegarian
author_sort Ahmad Nakhaei
title An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
title_short An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
title_full An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
title_fullStr An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
title_full_unstemmed An Efficient Green Approach for the Synthesis of Fluoroquinolones Using Nano Zirconia Sulfuric Acid as Highly Efficient Recyclable Catalyst in two Forms of Water
title_sort efficient green approach for the synthesis of fluoroquinolones using nano zirconia sulfuric acid as highly efficient recyclable catalyst in two forms of water
publisher Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
series Iranian Journal of Chemistry & Chemical Engineering
issn 1021-9986
1021-9986
publishDate 2018-06-01
description Various antibacterial fluoroquinolone compounds were prepared by the direct amination of 7-halo-6- fluoroquinolone-3-carboxylic acids with a variety of piperazine derivatives and (4aR,7aR)-octahydro-1H-pyrrolo[3,4-b] pyridine using Zirconia Sulfuric Acid (ZrSA) nanoparticle, as a catalyst in the presence of ordinary or magnetized water upon reflux condition. The results showed that ZrSA exhibited high catalytic activity towards the synthesis of fluoroquinolone derivatives in two forms of water. However, the magnetized water showed better results. Furthermore, the catalyst was recyclable and could be reused at least three times without any discernible loss in its catalytic activity. Overall, this new catalytic method for the synthesis of fluoroquinolone derivatives provides rapid access to the desired compounds in refluxing water following a simple work‐up procedure and avoids the use of harmful organic solvents. This method, therefore, represents a significant improvement over the methods currently available for the synthesis of fluoroquinolone derivatives.
topic fluoroquinolone derivatives
antibacterial
fast and green synthesis
zirconia sulfuric acid (zrsa)
ordinary or magnetized water
url http://www.ijcce.ac.ir/article_27405_c5f4d9ea1aa8e3af6b5f5a1397d45823.pdf
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