Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy

Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at t...

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Main Authors: Devon C. Crawford, Denise M. O. Ramirez, Brent Trauterman, Lisa M. Monteggia, Ege T. Kavalali
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14436
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spelling doaj-dc471629a1504a31be0f7fd4efcefb462021-05-11T07:39:17ZengNature Publishing GroupNature Communications2041-17232017-02-018111410.1038/ncomms14436Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacyDevon C. Crawford0Denise M. O. Ramirez1Brent Trauterman2Lisa M. Monteggia3Ege T. Kavalali4Department of Neuroscience, UT Southwestern Medical CenterDepartment of Neurology and Neurotherapeutics, Whole Brain Microscopy Facility, UT Southwestern Medical CenterDepartment of Neuroscience, UT Southwestern Medical CenterDepartment of Neuroscience, UT Southwestern Medical CenterDepartment of Neuroscience, UT Southwestern Medical CenterEmerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at the postsynaptic side in cultured neurons and alters synaptic plasticity in acute brain slices.https://doi.org/10.1038/ncomms14436
collection DOAJ
language English
format Article
sources DOAJ
author Devon C. Crawford
Denise M. O. Ramirez
Brent Trauterman
Lisa M. Monteggia
Ege T. Kavalali
spellingShingle Devon C. Crawford
Denise M. O. Ramirez
Brent Trauterman
Lisa M. Monteggia
Ege T. Kavalali
Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
Nature Communications
author_facet Devon C. Crawford
Denise M. O. Ramirez
Brent Trauterman
Lisa M. Monteggia
Ege T. Kavalali
author_sort Devon C. Crawford
title Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_short Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_full Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_fullStr Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_full_unstemmed Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
title_sort selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-02-01
description Emerging evidence suggests that spontaneous neurotransmitter release contributes to the maintenance of synaptic efficacy. Here the authors selectively reduce spontaneous glutamatergic transmission while leaving the stimulus-evoked responses intact and show that this leads to homeostatic scaling at the postsynaptic side in cultured neurons and alters synaptic plasticity in acute brain slices.
url https://doi.org/10.1038/ncomms14436
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AT denisemoramirez selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy
AT brenttrauterman selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy
AT lisammonteggia selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy
AT egetkavalali selectivemolecularimpairmentofspontaneousneurotransmissionmodulatessynapticefficacy
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