Comparison of Simple Eudragit Microparticles Loaded with Prednisolone and Eudragit-Coated Chitosan-Succinyl-Prednisolone Conjugate Microparticles: Part II. In Vivo Evaluation of Efficacy, Toxicity, and Biodisposition Characteristics

Comparison of Simple Eudragit Microparticles Loaded with Prednisolone and Eudragit-Coated Chitosan-Succinyl-Prednisolone Conjugate Microparticles: Part II. In Vivo Evaluation of Efficacy, Toxicity, and Biodisposition Characteristics

We previously prepared and evaluated simple Eudragit S100 microparticles loaded with prednisolone (ES-MP) and Eudragit S100-coated chitosan-succinyl-prednisolone conjugate microparticles (Ch-MP/ES) in vitro. In this work, the effectiveness, toxic side effects (5 mg prednisolone (PD) eq/kg × 3 d, 10...

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Bibliographic Details
Main Authors: Hiraku Onishi, Hisashi Kikuchi
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
simple Eudragit S100 microparticle
Eudragit S100-coated chitosan-succinyl-prednisolone conjugate microparticle
efficacy
toxicity
pharmacokinetic characteristics
2,4,6-trinitrobenzenesulfonic acid-induced
Online Access:http://www.mdpi.com/1422-0067/16/11/25949

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http://www.mdpi.com/1422-0067/16/11/25949

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