The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study

Background: Alveolar osteitis (AO) is an important postoperative problem with an incidence of 20% to 35% especially prevalent after the removal of mandibular molars. Fibrinolysis with subsequent loss of blood clotting is believed to be the general cause of AO. Objectives: This study aims to eval...

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Main Authors: K.P. Anand, Swadheena Patro, Abhijita Mohapatra, Sumita Mishra
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2015-09-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/6464/11267_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf
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spelling doaj-dc2d5a6a43f2410fbb767a97d94207e42020-11-25T02:48:06ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-09-0199ZC25ZC2810.7860/JCDR/2015/11267.6464The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind StudyK.P. Anand0Swadheena Patro1Abhijita Mohapatra2Sumita Mishra3Reader, Department of Endodontics, Yashwantrao Chawan Dental College, Ahmednagar, Maharashtra, India.Reader, Department of Endodontics, Institute of Dental Sciences, Bhubaneswar, India.Reader, Department of Prosthodontics, Institute of Dental Sciences, Bhubaneswar, India.Senior Lecturer, Department of Orthodontics, Institute of Dental Sciences, Bhubaneswar, India.Background: Alveolar osteitis (AO) is an important postoperative problem with an incidence of 20% to 35% especially prevalent after the removal of mandibular molars. Fibrinolysis with subsequent loss of blood clotting is believed to be the general cause of AO. Objectives: This study aims to evaluate the efficacy of tranexamic acid, an antifibrinolytic agent in comparison with a placebo with respect to the reduction of incidence of AO after the extraction of mandibular molars by using following parameters: Pain, disintegration of Clot, halitosis. Materials and Methods: A double blind study consisted of 60 patients, who underwent routine dental extractions of mandibular molar teeth. Group A (30 patients) requiring routine dental extractions of mandibular teeth was randomly selected and was administered a dose of tranexamic acid orally (Pause 500mg) one hour prior to extraction of teeth. Gel foam soaked in tranexamic acid (160mg) was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket to secure the gelfoam. Group B (30 patients); a placebo (crocin) was given orally one hour prior to the extraction and gel foam soaked in saline was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket. Pain was rated individually by each patient at 3rd, 7th, 14th day after extraction and the results was statistically analysed. Results: This study supports that the use of tranexamic acid both locally and systemically following the removal of the teeth reduces the incidence of AO associated with the extraction of mandibular molars. Conclusion: Tranexamic acid has several advantages also when used for simple dental extractions, namely: low cost and ready availability and therefore we recommend this treatment modality.https://jcdr.net/articles/PDF/6464/11267_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdfalveolar osteitisgel foamfibrinolysis
collection DOAJ
language English
format Article
sources DOAJ
author K.P. Anand
Swadheena Patro
Abhijita Mohapatra
Sumita Mishra
spellingShingle K.P. Anand
Swadheena Patro
Abhijita Mohapatra
Sumita Mishra
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
Journal of Clinical and Diagnostic Research
alveolar osteitis
gel foam
fibrinolysis
author_facet K.P. Anand
Swadheena Patro
Abhijita Mohapatra
Sumita Mishra
author_sort K.P. Anand
title The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
title_short The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
title_full The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
title_fullStr The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
title_full_unstemmed The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
title_sort efficacy of tranexamic acid in the reduction of incidence of dry socket: an institutional double blind study
publisher JCDR Research and Publications Private Limited
series Journal of Clinical and Diagnostic Research
issn 2249-782X
0973-709X
publishDate 2015-09-01
description Background: Alveolar osteitis (AO) is an important postoperative problem with an incidence of 20% to 35% especially prevalent after the removal of mandibular molars. Fibrinolysis with subsequent loss of blood clotting is believed to be the general cause of AO. Objectives: This study aims to evaluate the efficacy of tranexamic acid, an antifibrinolytic agent in comparison with a placebo with respect to the reduction of incidence of AO after the extraction of mandibular molars by using following parameters: Pain, disintegration of Clot, halitosis. Materials and Methods: A double blind study consisted of 60 patients, who underwent routine dental extractions of mandibular molar teeth. Group A (30 patients) requiring routine dental extractions of mandibular teeth was randomly selected and was administered a dose of tranexamic acid orally (Pause 500mg) one hour prior to extraction of teeth. Gel foam soaked in tranexamic acid (160mg) was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket to secure the gelfoam. Group B (30 patients); a placebo (crocin) was given orally one hour prior to the extraction and gel foam soaked in saline was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket. Pain was rated individually by each patient at 3rd, 7th, 14th day after extraction and the results was statistically analysed. Results: This study supports that the use of tranexamic acid both locally and systemically following the removal of the teeth reduces the incidence of AO associated with the extraction of mandibular molars. Conclusion: Tranexamic acid has several advantages also when used for simple dental extractions, namely: low cost and ready availability and therefore we recommend this treatment modality.
topic alveolar osteitis
gel foam
fibrinolysis
url https://jcdr.net/articles/PDF/6464/11267_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf
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