The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study
Background: Alveolar osteitis (AO) is an important postoperative problem with an incidence of 20% to 35% especially prevalent after the removal of mandibular molars. Fibrinolysis with subsequent loss of blood clotting is believed to be the general cause of AO. Objectives: This study aims to eval...
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doaj-dc2d5a6a43f2410fbb767a97d94207e42020-11-25T02:48:06ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-09-0199ZC25ZC2810.7860/JCDR/2015/11267.6464The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind StudyK.P. Anand0Swadheena Patro1Abhijita Mohapatra2Sumita Mishra3Reader, Department of Endodontics, Yashwantrao Chawan Dental College, Ahmednagar, Maharashtra, India.Reader, Department of Endodontics, Institute of Dental Sciences, Bhubaneswar, India.Reader, Department of Prosthodontics, Institute of Dental Sciences, Bhubaneswar, India.Senior Lecturer, Department of Orthodontics, Institute of Dental Sciences, Bhubaneswar, India.Background: Alveolar osteitis (AO) is an important postoperative problem with an incidence of 20% to 35% especially prevalent after the removal of mandibular molars. Fibrinolysis with subsequent loss of blood clotting is believed to be the general cause of AO. Objectives: This study aims to evaluate the efficacy of tranexamic acid, an antifibrinolytic agent in comparison with a placebo with respect to the reduction of incidence of AO after the extraction of mandibular molars by using following parameters: Pain, disintegration of Clot, halitosis. Materials and Methods: A double blind study consisted of 60 patients, who underwent routine dental extractions of mandibular molar teeth. Group A (30 patients) requiring routine dental extractions of mandibular teeth was randomly selected and was administered a dose of tranexamic acid orally (Pause 500mg) one hour prior to extraction of teeth. Gel foam soaked in tranexamic acid (160mg) was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket to secure the gelfoam. Group B (30 patients); a placebo (crocin) was given orally one hour prior to the extraction and gel foam soaked in saline was placed into the extraction socket postoperatively. A figure of eight silk suture was placed over the socket. Pain was rated individually by each patient at 3rd, 7th, 14th day after extraction and the results was statistically analysed. Results: This study supports that the use of tranexamic acid both locally and systemically following the removal of the teeth reduces the incidence of AO associated with the extraction of mandibular molars. Conclusion: Tranexamic acid has several advantages also when used for simple dental extractions, namely: low cost and ready availability and therefore we recommend this treatment modality.https://jcdr.net/articles/PDF/6464/11267_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdfalveolar osteitisgel foamfibrinolysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K.P. Anand Swadheena Patro Abhijita Mohapatra Sumita Mishra |
spellingShingle |
K.P. Anand Swadheena Patro Abhijita Mohapatra Sumita Mishra The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study Journal of Clinical and Diagnostic Research alveolar osteitis gel foam fibrinolysis |
author_facet |
K.P. Anand Swadheena Patro Abhijita Mohapatra Sumita Mishra |
author_sort |
K.P. Anand |
title |
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study |
title_short |
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study |
title_full |
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study |
title_fullStr |
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study |
title_full_unstemmed |
The Efficacy of Tranexamic Acid in the Reduction of Incidence of Dry Socket: An Institutional Double Blind Study |
title_sort |
efficacy of tranexamic acid in the reduction of incidence of dry socket: an institutional double blind study |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2015-09-01 |
description |
Background: Alveolar osteitis (AO) is an important postoperative
problem with an incidence of 20% to 35% especially prevalent after
the removal of mandibular molars. Fibrinolysis with subsequent
loss of blood clotting is believed to be the general cause of AO.
Objectives: This study aims to evaluate the efficacy of tranexamic
acid, an antifibrinolytic agent in comparison with a placebo with
respect to the reduction of incidence of AO after the extraction
of mandibular molars by using following parameters: Pain,
disintegration of Clot, halitosis.
Materials and Methods: A double blind study consisted of 60
patients, who underwent routine dental extractions of mandibular
molar teeth. Group A (30 patients) requiring routine dental extractions of mandibular teeth was randomly selected and was
administered a dose of tranexamic acid orally (Pause 500mg) one
hour prior to extraction of teeth. Gel foam soaked in tranexamic acid
(160mg) was placed into the extraction socket postoperatively.
A figure of eight silk suture was placed over the socket to secure
the gelfoam. Group B (30 patients); a placebo (crocin) was given
orally one hour prior to the extraction and gel foam soaked in saline
was placed into the extraction socket postoperatively. A figure
of eight silk suture was placed over the socket. Pain was rated
individually by each patient at 3rd, 7th, 14th day after extraction and
the results was statistically analysed.
Results: This study supports that the use of tranexamic acid both
locally and systemically following the removal of the teeth reduces
the incidence of AO associated with the extraction of mandibular
molars.
Conclusion: Tranexamic acid has several advantages also when
used for simple dental extractions, namely: low cost and ready
availability and therefore we recommend this treatment modality. |
topic |
alveolar osteitis gel foam fibrinolysis |
url |
https://jcdr.net/articles/PDF/6464/11267_CE(RA1)_F(T)_PF1(AGAK)_PFA(AK)_PF2(PAG).pdf |
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