β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata

β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata

Abstract Background Intracellular Ca2+ overload induced by extracellular Ca2+ entry has previously been confirmed to be an important mechanism for the cardiotoxicity as well as the acute heart dysfunction induced by jellyfish venom, while the underlying mechanism remains to be elucidated. Methods Un...

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Bibliographic Details
Main Authors: Qianqian Wang, Hui Zhang, Bo Wang, Chao Wang, Liang Xiao, Liming Zhang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Pharmacology and Toxicology
Subjects:
Cyanea capillata
Tentacle extract
β adrenergic receptor
Heart dysfunction
Propranolol
Online Access:http://link.springer.com/article/10.1186/s40360-017-0167-0

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