Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study

Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study

Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited n...

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Main Authors: Asahi Tomitaka, Tsutomu Yamada, Yasushi Takemura
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2012/480626
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spelling doaj-dc283c3d8a344579a22baefbbd3dfd222020-11-24T23:23:02ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292012-01-01201210.1155/2012/480626480626Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro StudyAsahi Tomitaka0Tsutomu Yamada1Yasushi Takemura2Institute of Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, JapanDepartment of Electrical and Computer Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, JapanDepartment of Electrical and Computer Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, JapanMagnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated Fe3O4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.http://dx.doi.org/10.1155/2012/480626
collection DOAJ
language English
format Article
sources DOAJ
author Asahi Tomitaka
Tsutomu Yamada
Yasushi Takemura
spellingShingle Asahi Tomitaka
Tsutomu Yamada
Yasushi Takemura
Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
Journal of Nanomaterials
author_facet Asahi Tomitaka
Tsutomu Yamada
Yasushi Takemura
author_sort Asahi Tomitaka
title Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
title_short Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
title_full Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
title_fullStr Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
title_full_unstemmed Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
title_sort magnetic nanoparticle hyperthermia using pluronic-coated fe3o4 nanoparticles: an in vitro study
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2012-01-01
description Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated Fe3O4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.
url http://dx.doi.org/10.1155/2012/480626
work_keys_str_mv AT asahitomitaka magneticnanoparticlehyperthermiausingpluroniccoatedfe3o4nanoparticlesaninvitrostudy
AT tsutomuyamada magneticnanoparticlehyperthermiausingpluroniccoatedfe3o4nanoparticlesaninvitrostudy
AT yasushitakemura magneticnanoparticlehyperthermiausingpluroniccoatedfe3o4nanoparticlesaninvitrostudy
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