Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study
Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited n...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2012-01-01
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| Series: | Journal of Nanomaterials |
| Online Access: | http://dx.doi.org/10.1155/2012/480626 |
| Summary: | Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4
nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated Fe3O4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis. |
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| ISSN: | 1687-4110 1687-4129 |