Random lasing in human tissues embedded with organic dyes for cancer diagnosis

Random lasing in human tissues embedded with organic dyes for cancer diagnosis

Abstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,...

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Main Authors: Yu Wang, Zhuojun Duan, Zhu Qiu, Peng Zhang, Jianwei Wu, Dingke Zhang, Tingxiu Xiang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08625-3
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spelling doaj-dc25f55894264a4883d1a782eea1da522020-12-08T00:20:52ZengNature Publishing GroupScientific Reports2045-23222017-08-01711710.1038/s41598-017-08625-3Random lasing in human tissues embedded with organic dyes for cancer diagnosisYu Wang0Zhuojun Duan1Zhu Qiu2Peng Zhang3Jianwei Wu4Dingke Zhang5Tingxiu Xiang6School of Physics and Electronic Engineering, Chongqing Normal UniversitySchool of Physics and Electronic Engineering, Chongqing Normal UniversityChongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical UniversitySchool of Physics and Electronic Engineering, Chongqing Normal UniversitySchool of Physics and Electronic Engineering, Chongqing Normal UniversitySchool of Physics and Electronic Engineering, Chongqing Normal UniversityChongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB). Hematoxylin and eosin stain images show that there are more laser resonators in cancerous tissues, caused by a large number of disordered scatters. It is also noteworthy that the random lasing thresholds were found to relate to the tumor malignancy grade. Consequently, the resulting typical random lasing resonators differ between cancerous tissues in different malignancy grades. Further studies are warranted to investigate tissue optical spectroscopy in the field of cancer diagnostics.https://doi.org/10.1038/s41598-017-08625-3
collection DOAJ
language English
format Article
sources DOAJ
author Yu Wang
Zhuojun Duan
Zhu Qiu
Peng Zhang
Jianwei Wu
Dingke Zhang
Tingxiu Xiang
spellingShingle Yu Wang
Zhuojun Duan
Zhu Qiu
Peng Zhang
Jianwei Wu
Dingke Zhang
Tingxiu Xiang
Random lasing in human tissues embedded with organic dyes for cancer diagnosis
Scientific Reports
author_facet Yu Wang
Zhuojun Duan
Zhu Qiu
Peng Zhang
Jianwei Wu
Dingke Zhang
Tingxiu Xiang
author_sort Yu Wang
title Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_short Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_full Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_fullStr Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_full_unstemmed Random lasing in human tissues embedded with organic dyes for cancer diagnosis
title_sort random lasing in human tissues embedded with organic dyes for cancer diagnosis
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-08-01
description Abstract Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB). Hematoxylin and eosin stain images show that there are more laser resonators in cancerous tissues, caused by a large number of disordered scatters. It is also noteworthy that the random lasing thresholds were found to relate to the tumor malignancy grade. Consequently, the resulting typical random lasing resonators differ between cancerous tissues in different malignancy grades. Further studies are warranted to investigate tissue optical spectroscopy in the field of cancer diagnostics.
url https://doi.org/10.1038/s41598-017-08625-3
work_keys_str_mv AT yuwang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT zhuojunduan randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT zhuqiu randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT pengzhang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT jianweiwu randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT dingkezhang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
AT tingxiuxiang randomlasinginhumantissuesembeddedwithorganicdyesforcancerdiagnosis
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