Development of the Rat Model of Lapatinib-Induced Diarrhoea

Development of the Rat Model of Lapatinib-Induced Diarrhoea

Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understandin...

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Main Author: Joanne M. Bowen
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/2014/194185
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spelling doaj-dc22c394f5a64f448decb55e2b4eada92020-11-25T01:13:22ZengHindawi LimitedScientifica2090-908X2014-01-01201410.1155/2014/194185194185Development of the Rat Model of Lapatinib-Induced DiarrhoeaJoanne M. Bowen0School of Medical Sciences, University of Adelaide, Frome Road, Adelaide, SA 5005, AustraliaTargeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understanding of EGFR TKI-induced diarrhoea has been limited to clinical observation. However, our group has recently developed the first rat model of EGFR TKI-induced diarrhoea. This paper reviews the published and unpublished findings.http://dx.doi.org/10.1155/2014/194185
collection DOAJ
language English
format Article
sources DOAJ
author Joanne M. Bowen
spellingShingle Joanne M. Bowen
Development of the Rat Model of Lapatinib-Induced Diarrhoea
Scientifica
author_facet Joanne M. Bowen
author_sort Joanne M. Bowen
title Development of the Rat Model of Lapatinib-Induced Diarrhoea
title_short Development of the Rat Model of Lapatinib-Induced Diarrhoea
title_full Development of the Rat Model of Lapatinib-Induced Diarrhoea
title_fullStr Development of the Rat Model of Lapatinib-Induced Diarrhoea
title_full_unstemmed Development of the Rat Model of Lapatinib-Induced Diarrhoea
title_sort development of the rat model of lapatinib-induced diarrhoea
publisher Hindawi Limited
series Scientifica
issn 2090-908X
publishDate 2014-01-01
description Targeted therapy of cancer is often associated with clinically significant diarrhoea; however, the mechanisms underpinning this adverse effect are currently unknown. Diarrhoea following treatment with tyrosine kinase inhibitors (TKIs) of EGFR is particularly troublesome. Until recently, understanding of EGFR TKI-induced diarrhoea has been limited to clinical observation. However, our group has recently developed the first rat model of EGFR TKI-induced diarrhoea. This paper reviews the published and unpublished findings.
url http://dx.doi.org/10.1155/2014/194185
work_keys_str_mv AT joannembowen developmentoftheratmodeloflapatinibinduceddiarrhoea
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