Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological Relevance

While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely acknowledged that the environment plays a significant role in the etiology of neurodegenerative diseases. Epidemiological evidence suggests that occupational exposure to pesticides (e.g., dieldri...

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Bibliographic Details
Main Authors: Fangjie Cao, Christopher L. Souders II, Veronica Perez-Rodriguez, Christopher J. Martyniuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Genetics
Subjects:
neurodegeneration
pesticides
mitochondria
gene networks
adverse outcome pathways
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00701/full

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