Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis

Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis

ObjectiveT-cells are critical players in the pathogenesis of osteoporosis in patients with rheumatoid arthritis (RA). Premature senescence of lymphocytes including the accumulation of senescent CD4+ T-cells is a hallmark feature of RA. Whether T-cell senescence is associated with bone loss in RA pat...

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Bibliographic Details
Main Authors: Johannes Fessler, Rusmir Husic, Verena Schwetz, Elisabeth Lerchbaum, Felix Aberer, Patrizia Fasching, Anja Ficjan, Barbara Obermayer-Pietsch, Christina Duftner, Winfried Graninger, Martin Helmut Stradner, Christian Dejaco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
T-lymphocyte
rheumatoid arthritis
osteoporosis
aging
IL-15
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00095/full

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