CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study

• Main Authors: Erinaldo Ubirajara Damasceno dos Santos, Géssica Dayane Cordeiro de Lima, Micheline de Lucena Oliveira, Sandra de Andrade Heráclio, Hildson Dornelas Angelo da Silva, Sergio Crovella, Maria de Mascena Diniz Maia, Paulo Roberto Eleutério de Souza/
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 2016-03-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: chemokine receptors; cervical intraepithelial neoplasia; cervical cancer; single nucleotide polymorphism
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000300174&lng=en&tlng=en

Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.