Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.

Bibliographic Details
Main Authors: Peiman Shooshtarizadeh, Anne Helness, Charles Vadnais, Nelleke Brouwer, Hugues Beauchemin, Riyan Chen, Halil Bagci, Frank J. T. Staal, Jean-François Coté, Tarik Möröy
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09273-z
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spelling doaj-dc1d6a2a5faa46caa688da1feb30cd2a2021-05-11T12:37:38ZengNature Publishing GroupNature Communications2041-17232019-03-0110111610.1038/s41467-019-09273-zGfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytesPeiman Shooshtarizadeh0Anne Helness1Charles Vadnais2Nelleke Brouwer3Hugues Beauchemin4Riyan Chen5Halil Bagci6Frank J. T. Staal7Jean-François Coté8Tarik Möröy9Institut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalDepartment of Immunohematology and Bloodtransfusion, Leiden University Medical CenterInstitut de recherches cliniques de MontréalInstitut de recherches cliniques de MontréalGfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.https://doi.org/10.1038/s41467-019-09273-z
collection DOAJ
language English
format Article
sources DOAJ
author Peiman Shooshtarizadeh
Anne Helness
Charles Vadnais
Nelleke Brouwer
Hugues Beauchemin
Riyan Chen
Halil Bagci
Frank J. T. Staal
Jean-François Coté
Tarik Möröy
spellingShingle Peiman Shooshtarizadeh
Anne Helness
Charles Vadnais
Nelleke Brouwer
Hugues Beauchemin
Riyan Chen
Halil Bagci
Frank J. T. Staal
Jean-François Coté
Tarik Möröy
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
Nature Communications
author_facet Peiman Shooshtarizadeh
Anne Helness
Charles Vadnais
Nelleke Brouwer
Hugues Beauchemin
Riyan Chen
Halil Bagci
Frank J. T. Staal
Jean-François Coté
Tarik Möröy
author_sort Peiman Shooshtarizadeh
title Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_short Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_full Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_fullStr Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_full_unstemmed Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
title_sort gfi1b regulates the level of wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-03-01
description Gfi1b regulates cellularity of haematopoietic stem cells (HSCs) and megakaryocytes (MKs) as well as spreading of MKs on matrix. Here the authors show that Gfi1b regulates this behaviour by recruiting LSD1 and β-catenin to Wnt/β-catenin signalling targets.
url https://doi.org/10.1038/s41467-019-09273-z
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AT tarikmoroy gfi1bregulatesthelevelofwntbcateninsignalinginhematopoieticstemcellsandmegakaryocytes
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