Iron imaging in myocardial infarction reperfusion injury

Restoration of coronary blood flow after a heart attack may lead to reperfusion injury and pathologic iron deposition. Here, the authors perform magnetic susceptibility imaging showing its association with iron in a large animal model of myocardial infarction during wound healing, and showing feasib...

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Main Authors:	Brianna F. Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P. Solomon, Anya T. Hall, Rishabh Kumar, Nicholas J. Josselyn, Elizabeth M. Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J. Pilla, Joseph H. Gorman, Robert C. Gorman, Cory Tschabrunn, Samuel J. Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W. Wehrli, Haochang Shou, Victor A. Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai, Walter R. Witschey
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16923-0

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spelling	doaj-dc0dc96d8d144bd499b64b7fc318dcc82021-07-04T11:46:56ZengNature Publishing GroupNature Communications2041-17232020-06-0111111410.1038/s41467-020-16923-0Iron imaging in myocardial infarction reperfusion injuryBrianna F. Moon0Srikant Kamesh Iyer1Eileen Hwuang2Michael P. Solomon3Anya T. Hall4Rishabh Kumar5Nicholas J. Josselyn6Elizabeth M. Higbee-Dempsey7Andrew Tsourkas8Akito Imai9Keitaro Okamoto10Yoshiaki Saito11James J. Pilla12Joseph H. Gorman13Robert C. Gorman14Cory Tschabrunn15Samuel J. Keeney16Estibaliz Castillero17Giovanni Ferrari18Steffen Jockusch19Felix W. Wehrli20Haochang Shou21Victor A. Ferrari22Yuchi Han23Avanti Gulhane24Harold Litt25William Matthai26Walter R. Witschey27Department of Bioengineering, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Biophysics, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaBiochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Perelman School of Medicine, University of PennsylvaniaDepartment of Surgery, Columbia University Irving Medical CenterDepartment of Surgery, Columbia University Irving Medical CenterDepartment of Chemistry, Columbia UniversityDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine, Perelman School of Medicine, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Medicine, Penn Presbyterian Medical Center, University of PennsylvaniaDepartment of Bioengineering, University of PennsylvaniaRestoration of coronary blood flow after a heart attack may lead to reperfusion injury and pathologic iron deposition. Here, the authors perform magnetic susceptibility imaging showing its association with iron in a large animal model of myocardial infarction during wound healing, and showing feasibility in acute myocardial infarction patients undergoing percutaneous coronary intervention.https://doi.org/10.1038/s41467-020-16923-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Brianna F. Moon Srikant Kamesh Iyer Eileen Hwuang Michael P. Solomon Anya T. Hall Rishabh Kumar Nicholas J. Josselyn Elizabeth M. Higbee-Dempsey Andrew Tsourkas Akito Imai Keitaro Okamoto Yoshiaki Saito James J. Pilla Joseph H. Gorman Robert C. Gorman Cory Tschabrunn Samuel J. Keeney Estibaliz Castillero Giovanni Ferrari Steffen Jockusch Felix W. Wehrli Haochang Shou Victor A. Ferrari Yuchi Han Avanti Gulhane Harold Litt William Matthai Walter R. Witschey
spellingShingle	Brianna F. Moon Srikant Kamesh Iyer Eileen Hwuang Michael P. Solomon Anya T. Hall Rishabh Kumar Nicholas J. Josselyn Elizabeth M. Higbee-Dempsey Andrew Tsourkas Akito Imai Keitaro Okamoto Yoshiaki Saito James J. Pilla Joseph H. Gorman Robert C. Gorman Cory Tschabrunn Samuel J. Keeney Estibaliz Castillero Giovanni Ferrari Steffen Jockusch Felix W. Wehrli Haochang Shou Victor A. Ferrari Yuchi Han Avanti Gulhane Harold Litt William Matthai Walter R. Witschey Iron imaging in myocardial infarction reperfusion injury Nature Communications
author_facet	Brianna F. Moon Srikant Kamesh Iyer Eileen Hwuang Michael P. Solomon Anya T. Hall Rishabh Kumar Nicholas J. Josselyn Elizabeth M. Higbee-Dempsey Andrew Tsourkas Akito Imai Keitaro Okamoto Yoshiaki Saito James J. Pilla Joseph H. Gorman Robert C. Gorman Cory Tschabrunn Samuel J. Keeney Estibaliz Castillero Giovanni Ferrari Steffen Jockusch Felix W. Wehrli Haochang Shou Victor A. Ferrari Yuchi Han Avanti Gulhane Harold Litt William Matthai Walter R. Witschey
author_sort	Brianna F. Moon
title	Iron imaging in myocardial infarction reperfusion injury
title_short	Iron imaging in myocardial infarction reperfusion injury
title_full	Iron imaging in myocardial infarction reperfusion injury
title_fullStr	Iron imaging in myocardial infarction reperfusion injury
title_full_unstemmed	Iron imaging in myocardial infarction reperfusion injury
title_sort	iron imaging in myocardial infarction reperfusion injury
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Restoration of coronary blood flow after a heart attack may lead to reperfusion injury and pathologic iron deposition. Here, the authors perform magnetic susceptibility imaging showing its association with iron in a large animal model of myocardial infarction during wound healing, and showing feasibility in acute myocardial infarction patients undergoing percutaneous coronary intervention.
url	https://doi.org/10.1038/s41467-020-16923-0
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Iron imaging in myocardial infarction reperfusion injury

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