Probing Multi-Target Action of Phlorotannins as New Monoamine Oxidase Inhibitors and Dopaminergic Receptor Modulators with the Potential for Treatment of Neuronal Disorders

Probing Multi-Target Action of Phlorotannins as New Monoamine Oxidase Inhibitors and Dopaminergic Receptor Modulators with the Potential for Treatment of Neuronal Disorders

Modulation of multiple protein targets with a single compound is essential for the effective treatment of central nervous system disorders. In our previous G protein-coupled receptor (GPCR) cell-based study, a selective human monoamine oxidase (<i>h</i>MAO)-A inhibitor, eckol, stimulated...

Full description

Bibliographic Details
Main Authors: Su Hui Seong, Pradeep Paudel, Jeong-Wook Choi, Dong Hyun Ahn, Taek-Jeong Nam, Hyun Ah Jung, Jae Sue Choi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
phlorotannin
phlorofucofuroeckol-A
dieckol
monoamine oxidase
dopamine receptor
GPCR
computational docking
Online Access:https://www.mdpi.com/1660-3397/17/6/377

Internet

https://www.mdpi.com/1660-3397/17/6/377

Similar Items