Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension

Macrophage Depletion Improves Endothelial Insulin Resistance and Protects against Cardiovascular Injury in Salt-Sensitive Hypertension

Vascular endothelial insulin signaling is critical for the maintenance of vascular and metabolic homeostasis. We have previously shown that in hypertensive Dahl rats, impaired vascular insulin action is linked to angiotensin II activation of the NFκB inflammatory pathway. Macrophage polarization (M1...

Full description

Bibliographic Details
Main Authors:	Yue-Yang Liu, Jun Luo, Ruiping Cai, Junjie Zhang, Qian Xu, Yuantong Tian, Ming-Sheng Zhou
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2020/5073762

Similar Items

Tumor Necrosis Factor Alpha Deficiency Improves Endothelial Function and Cardiovascular Injury in Deoxycorticosterone Acetate/Salt-Hypertensive Mice
by: Ruiping Cai, et al.
Published: (2020-01-01)

Macrophage Depletion Lowered Blood Pressure and Attenuated Hypertensive Renal Injury and Fibrosis
by: Lei Huang, et al.
Published: (2018-05-01)

Serum insulin concentrations, insulin sensitivity, and endothelial function in essential hypertension and non-insulin-dependent diabetes mellitus
by: Petrie, John Ross
Published: (1997)

Effect of angiotensin-converting enzyme inhibition on endothelial function and insulin sensitivity in hypertensive patients
by: Hakan Tezcan, et al.
Published: (2003-06-01)

Salt, Hypertension and Cardiovascular Disease: the Connection
by: Arieska Ann Soenarta
Published: (2013-06-01)

Development of Salt-Sensitive Hypertension in Hydronephrosis
by: Carlström, Mattias
Published: (2008)

Role of Rho in Salt-Sensitive Hypertension
by: Wakako Kawarazaki, et al.
Published: (2021-03-01)

Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity
by: Lucie Orliaguet, et al.
Published: (2020-02-01)

Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients
by: Dilek Yavuz, et al.
Published: (2003-09-01)

The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats
by: Fernandez Rayne, et al.
Published: (2010-08-01)

Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
by: Shehata Marlene F
Published: (2008-04-01)

Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men
by: Giulia Dell'omo, et al.
Published: (2014-01-01)

Q192R Paraoxonase (PON)1 Polymorphism, Insulin Sensitivity, and Endothelial Function in Essential Hypertensive Men
by: Giulia Dell’Omo, et al.
Published: (2014-07-01)

The hot button issue of salt-sensitive hypertension
by: Dewan S. A. Majid, et al.
Published: (2016-01-01)

Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion
by: Mario Tirone, et al.
Published: (2019-07-01)

Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats
by: Xu Yang, et al.
Published: (2020-01-01)

Salt and insulin sensitivity after short and prolonged high salt intake in elderly subjects
by: N.K.C. Lima, et al.
Published: (2009-08-01)

Effects of Macrophage Depletion on Sleep in Mice.
by: Conner Ames, et al.
Published: (2016-01-01)

Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19
by: Xinbei Tian, et al.
Published: (2021-06-01)

Renal Glomerular Mitochondria Function in Salt-Sensitive Hypertension
by: Mark Domondon, et al.
Published: (2020-02-01)

Endogenous central signaling mechanisms in salt-sensitive hypertension
by: Carmichael, Casey Yumi
Published: (2016)

Mitochondrial DNA depletion and insulin secretion
by: Hine, Donna Louise
Published: (2013)

SALT INTAKE, ARTERIAL HYPERTENSION, AND CARDIOVASCULAR RISK. PART I
by: N. G. Poteshkina
Published: (2011-06-01)

SALT INTAKE, ARTERIAL HYPERTENSION, AND CARDIOVASCULAR RISK. PART II
by: N. G. Poteshkina
Published: (2011-10-01)

Investigation of the ethnic differences and genetics of salt sensivity and salt-sensitive hypertension in South Africa
by: Rayner, Brian L
Published: (2014)

Endothelial dysfunction in hypertension: pathophysiological mechanism or marker of cardiovascular risk?
by: Lorenzo Ghiadoni, et al.
Published: (2013-03-01)

Endothelial dysfunction in arterial hypertension - cardiovascular complication risk factor
by: B. A. Namakanov, et al.
Published: (2005-12-01)

Can restoration of endothelial insulin sensitivity rescue vascular function and repair in systemic insulin resistance?
by: Sengupta, Anshuman
Published: (2015)

Sevoflurane depletes macrophages from the melanoma microenvironment.
by: Isabella Sztwiertnia, et al.
Published: (2020-01-01)

Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
by: Shehata Marlene F
Published: (2008-06-01)

Effect of Scurrula atropurpurea on nitric oxide, endothelial damage, and endothelial progenitor cells of DOCA-salt hypertensive rats
by: Nour Athiroh, et al.
Published: (2014-08-01)

Contribution of the sympathetic nervous system to the pathogenesis of salt-sensitive hypertension
by: Pazzol, Michael Lee
Published: (2016)

Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high-salt induced hypertensive mice: Role ofoxidative stress and endothelial dysfunction
by: Xiao-yun Wang, et al.
Published: (2019-07-01)

Role of macrophages in exercise-induced enhancement of insulin sensitivity in skeletal muscle
by: Shin-ichi Ikeda, et al.
Published: (2013-06-01)

The Fluorescence Depletion Properties of Insulin-Gold Nanoclusters
by: Po-Fu Chen, et al.
Published: (2014)

Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension
by: Gang eWang, et al.
Published: (2014-09-01)

P.050 THE INSULIN SENSITIZER ROSIGLITAZONE IMPROVES ENDOTHELIAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES ON INSULIN
by: K. Papathanassiou*, et al.
Published: (2007-06-01)

Finnish Diabetes Risk Score Is Associated with Impaired Insulin Secretion and Insulin Sensitivity, Drug-Treated Hypertension and Cardiovascular Disease: A Follow-Up Study of the METSIM Cohort.
by: Maria Fizelova, et al.
Published: (2016-01-01)

Macrophage depletion disrupts immune balance and energy homeostasis.
by: Bonggi Lee, et al.
Published: (2014-01-01)

Renal mechanisms contributing to blood pressure and the development of salt-sensitive hypertension
by: Puleo, Franco Jimmy
Published: (2020)