Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.

Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.

Activated protein C (APC) is a serine protease that has both anticoagulant and cytoprotective properties. The cytoprotective effects are protease activated receptor 1 (PAR-1) and endothelial protein C receptor (EPCR) dependent and likely underlie protective effects of APC in animal models of sepsis,...

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Bibliographic Details
Main Authors: Karin C A A Wildhagen, Roy Schrijver, Linda Beckers, Hugo ten Cate, Chris P M Reutelingsperger, Esther Lutgens, Gerry A F Nicolaes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4102480?pdf=render

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