Progressive multifocal leukoencephalopathy restricted to the posterior fossa in a patient with systemic lupus erythematosus

• Main Authors: Fabrício Guimarães Gonçalves, Leslie Lamb, Raquel Del Carpio-O'Donovan
• Format: Article
• Language: English
• Published: Elsevier
• Series: Brazilian Journal of Infectious Diseases
• Subjects: PML; leukoencephalopathy; progressive multifocal posterior fossa; magnetic resonance; spectroscopy; diffusion weighted images
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600020&lng=en&tlng=en

Progressive multifocal leukoencephalopathy is a neurological infectious disease caused by the John Cunningham polyomavirus (JCV), an opportunistic agent with worldwide distribution. This disease is frequently seen in immunosuppresed patients and rarely associated with systemic lupus erythematosus. In the central nervous system PML demyelinating lesions occur in the supratentorial compartment. The authors describe a rare case of PML secondary to SLE treatment with atypical presentation restricted to the posterior fossa.