HCV Animal Models: A Journey of More than 30 Years

• Main Authors: Philip Meuleman, Geert Leroux-Roels
• Format: Article
• Language: English
• Published: MDPI AG 2009-09-01
• Series: Viruses
• Subjects: HCV; animal model; chimpanzee; chimeric mice; uPA-SCID; hepatitis C; antiviral therapy; neutralizing antibodies
• Online Access: http://www.mdpi.com/1999-4915/1/2/222/

In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation. In 1989, the hepatitis C virus (HCV) was discovered and found to be the major causative agent of these infections. Because of its narrow ropism, the in vivo study of this virus was, especially in the early days, limited to the chimpanzee. In the past decade, several alternative animal models have been created. In this review we review these novel animal models and their contribution to our current understanding of the biology of HCV.