Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality

Yulin Zhang,1 Yi Li,2 Ji Zeng,3 Yanzi Chang,4 Shouhua Han,5 Jiankang Zhao,1 Yanyan Fan,1 Zhujia Xiong,1 Xiaohui Zou,1 Chunlei Wang,1 Binbin Li,1 Haibo Li,1 Jiajing Han,1 Xinmeng Liu,1 Yudi Xia,1 Binghuai Lu,1 Bin Cao1,6,7 1Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Mi...

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Main Authors: Zhang Y, Li Y, Zeng J, Chang Y, Han S, Zhao J, Fan Y, Xiong Z, Zou X, Wang C, Li B, Li H, Han J, Liu X, Xia Y, Lu B, Cao B
Format: Article
Language:English
Published: Dove Medical Press 2020-11-01
Series:Infection and Drug Resistance
Subjects:
Online Access:https://www.dovepress.com/risk-factors-for-mortality-of-inpatients-with-pseudomonas-aeruginosa-b-peer-reviewed-article-IDR
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spelling doaj-dbea5d8964264431b129c77fb0ecbfc62020-11-25T04:05:32ZengDove Medical PressInfection and Drug Resistance1178-69732020-11-01Volume 134115412359225Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the MortalityZhang YLi YZeng JChang YHan SZhao JFan YXiong ZZou XWang CLi BLi HHan JLiu XXia YLu BCao BYulin Zhang,1 Yi Li,2 Ji Zeng,3 Yanzi Chang,4 Shouhua Han,5 Jiankang Zhao,1 Yanyan Fan,1 Zhujia Xiong,1 Xiaohui Zou,1 Chunlei Wang,1 Binbin Li,1 Haibo Li,1 Jiajing Han,1 Xinmeng Liu,1 Yudi Xia,1 Binghuai Lu,1 Bin Cao1,6,7 1Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Department of Laboratory Medicine, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Laboratory Medicine, Wuhan Pu Ai Hospital of Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Department of Laboratory Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, People’s Republic of China; 5Department of Laboratory Medicine, Weifang No.2 People’s Hospital, Weifang, People’s Republic of China; 6Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, People’s Republic of China; 7Tsinghua University-Peking University, Joint Center for Life Sciences, Beijing, People’s Republic of ChinaCorrespondence: Binghuai Lu; Bin CaoDepartment of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, People’s Republic of ChinaTel/Fax +86-10-84206257Email zs25041@126.com; caobin_ben@163.comPurpose: Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with P. aeruginosa bacteremia in China remain unclear.Patients and Methods: This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed P. aeruginosa bacteremia in five healthcare centers in China during the years 2012– 2019.Results: Of 215 patients with P. aeruginosa bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P< 0.001) and carbapenem-resistant P. aeruginosa (CRPA) phenotype (OR=4.485, P=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant P. aeruginosa (MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank, P< 0.05).Conclusion: This study revealed a high mortality rate amongst hospitalized patients with P. aeruginosa bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.Keywords: risk factors, mortality, Pseudomonas aeruginosa, bacteremiahttps://www.dovepress.com/risk-factors-for-mortality-of-inpatients-with-pseudomonas-aeruginosa-b-peer-reviewed-article-IDRrisk factorsmortalitypseudomonas aeruginosabacteremia.
collection DOAJ
language English
format Article
sources DOAJ
author Zhang Y
Li Y
Zeng J
Chang Y
Han S
Zhao J
Fan Y
Xiong Z
Zou X
Wang C
Li B
Li H
Han J
Liu X
Xia Y
Lu B
Cao B
spellingShingle Zhang Y
Li Y
Zeng J
Chang Y
Han S
Zhao J
Fan Y
Xiong Z
Zou X
Wang C
Li B
Li H
Han J
Liu X
Xia Y
Lu B
Cao B
Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
Infection and Drug Resistance
risk factors
mortality
pseudomonas aeruginosa
bacteremia.
author_facet Zhang Y
Li Y
Zeng J
Chang Y
Han S
Zhao J
Fan Y
Xiong Z
Zou X
Wang C
Li B
Li H
Han J
Liu X
Xia Y
Lu B
Cao B
author_sort Zhang Y
title Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
title_short Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
title_full Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
title_fullStr Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
title_full_unstemmed Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality
title_sort risk factors for mortality of inpatients with pseudomonas aeruginosa bacteremia in china: impact of resistance profile in the mortality
publisher Dove Medical Press
series Infection and Drug Resistance
issn 1178-6973
publishDate 2020-11-01
description Yulin Zhang,1 Yi Li,2 Ji Zeng,3 Yanzi Chang,4 Shouhua Han,5 Jiankang Zhao,1 Yanyan Fan,1 Zhujia Xiong,1 Xiaohui Zou,1 Chunlei Wang,1 Binbin Li,1 Haibo Li,1 Jiajing Han,1 Xinmeng Liu,1 Yudi Xia,1 Binghuai Lu,1 Bin Cao1,6,7 1Department of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Beijing 100029, People’s Republic of China; 2Department of Laboratory Medicine, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Laboratory Medicine, Wuhan Pu Ai Hospital of Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Department of Laboratory Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, People’s Republic of China; 5Department of Laboratory Medicine, Weifang No.2 People’s Hospital, Weifang, People’s Republic of China; 6Clinical Center for Pulmonary Infections, Capital Medical University, Beijing, People’s Republic of China; 7Tsinghua University-Peking University, Joint Center for Life Sciences, Beijing, People’s Republic of ChinaCorrespondence: Binghuai Lu; Bin CaoDepartment of Pulmonary and Critical Care Medicine, Laboratory of Clinical Microbiology and Infectious Diseases, Center for Respiratory Diseases, National Clinical Research Center of Respiratory Diseases, China-Japan Friendship Hospital, Chaoyang District, Beijing 100029, People’s Republic of ChinaTel/Fax +86-10-84206257Email zs25041@126.com; caobin_ben@163.comPurpose: Pseudomonas aeruginosa bacteremia presents a severe challenge to hospitalized patients. However, to date, the risk factors for mortality among inpatients with P. aeruginosa bacteremia in China remain unclear.Patients and Methods: This retrospective multicenter study was performed to analyze 215 patients with culture-confirmed P. aeruginosa bacteremia in five healthcare centers in China during the years 2012– 2019.Results: Of 215 patients with P. aeruginosa bacteremia, 61 (28.4%) died during the study period. Logistic multivariable analysis revealed that cardiovascular disease (OR=3.978, P=0.001), blood transfusion (OR=5.855, P< 0.001) and carbapenem-resistant P. aeruginosa (CRPA) phenotype (OR=4.485, P=0.038) constituted the independent risk factors of mortality. Furthermore, both CRPA and multidrug-resistant P. aeruginosa (MDRPA) phenotypes were found to be significantly associated with 5-day mortality (Log-rank, P< 0.05).Conclusion: This study revealed a high mortality rate amongst hospitalized patients with P. aeruginosa bacteremia, and those with cardiovascular diseases, CRPA and MDRPA phenotypes, should be highlighted and given appropriate management in China.Keywords: risk factors, mortality, Pseudomonas aeruginosa, bacteremia
topic risk factors
mortality
pseudomonas aeruginosa
bacteremia.
url https://www.dovepress.com/risk-factors-for-mortality-of-inpatients-with-pseudomonas-aeruginosa-b-peer-reviewed-article-IDR
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