Non-Lethal Levels of Oxidative Stress in Response to Short-Term Intermittent Hypoxia Enhance Ca2+ Handling in Neonatal Rat Cardiomyocytes

Non-Lethal Levels of Oxidative Stress in Response to Short-Term Intermittent Hypoxia Enhance Ca2+ Handling in Neonatal Rat Cardiomyocytes

Background/Aims: Intermittent hypoxia (IH) may exert pre-conditioning-like cardioprotective effects and alter Ca2+ regulation; however, the exact mechanism of these effects remains unclear. Thus, we examined Ca2+-handling mechanisms induced by IH in rat neonatal cardiomyocytes. Methods: Cardiomyocyt...

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Bibliographic Details
Main Authors: Tsung-I Chen, Yu-Cheng Hsu, Chih-Feng Lien, Jian-Hong Lin, Hung-Wen Chiu, Kun-Ta Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Reactive oxygen species
Calcium regulation
Sarcoplasmic reticulum Ca2+ ATPase
Sodium calcium exchanger
Protein kinase C
Intermittent hypoxia
Online Access:http://www.karger.com/Article/FullText/358631

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