Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa)
Mucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invas...
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Elsevier
2020-12-01
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| Series: | Medical Mycology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753920300580 |
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doaj-dbe8db70ba2248a0906be570c699cd412020-12-17T04:48:18ZengElsevierMedical Mycology Case Reports2211-75392020-12-01303942Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa)E.M. Spithoven0A.H.W. Bruns1B.J. Petri2P.J. Haas3T.Q. Nguyen4F. Hagen5A.D. van Zuilen6Department of Nephrology, Internal Medicine, University Medical Center Utrecht, Utrecht, the Netherlands; Corresponding author. Department of Nephrology, Internal Medicine, University Medical Center UtrechtHeidelberglaan 100, 3584 CX Utrecht, the Netherlands.Department of Infectious Diseases, Internal Medicine, University Medical Center Utrecht, Utrecht, the NetherlandsDepartment of Vascular Surgery, Surgery Department, University Medical Center Utrecht, Utrecht, the NetherlandsDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the NetherlandsDepartment of Pathology, University Medical Center Utrecht, Utrecht, the NetherlandsDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Medical Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, the NetherlandsDepartment of Nephrology, Internal Medicine, University Medical Center Utrecht, Utrecht, the NetherlandsMucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invasive mucormycosis. In this patient, we used a step-wise approach of withdrawal of immunosuppressants, antifungal induction therapy, extensive surgical debridement of all (potentially) infected tissue, abdominal irrigation of liposomal amphotericin B and interferon gamma. Due to rapid diagnosis and intensive therapy the patient survived.http://www.sciencedirect.com/science/article/pii/S2211753920300580mucormycosisRenal transplantInterferon gammaSurvival |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
E.M. Spithoven A.H.W. Bruns B.J. Petri P.J. Haas T.Q. Nguyen F. Hagen A.D. van Zuilen |
| spellingShingle |
E.M. Spithoven A.H.W. Bruns B.J. Petri P.J. Haas T.Q. Nguyen F. Hagen A.D. van Zuilen Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) Medical Mycology Case Reports mucormycosis Renal transplant Interferon gamma Survival |
| author_facet |
E.M. Spithoven A.H.W. Bruns B.J. Petri P.J. Haas T.Q. Nguyen F. Hagen A.D. van Zuilen |
| author_sort |
E.M. Spithoven |
| title |
Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) |
| title_short |
Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) |
| title_full |
Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) |
| title_fullStr |
Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) |
| title_full_unstemmed |
Renal transplant patient survives a donor-derived abdominal invasive mucormycosis (Lichtheimia ramosa) |
| title_sort |
renal transplant patient survives a donor-derived abdominal invasive mucormycosis (lichtheimia ramosa) |
| publisher |
Elsevier |
| series |
Medical Mycology Case Reports |
| issn |
2211-7539 |
| publishDate |
2020-12-01 |
| description |
Mucormycosis is a life-threatening invasive fungal infection, most commonly described in severely immunocompromised patients. It is characterized by rapid invasive growth of the fungus and often with fatal outcome. We report a case of a renal transplant recipient diagnosed with a donor-derived invasive mucormycosis. In this patient, we used a step-wise approach of withdrawal of immunosuppressants, antifungal induction therapy, extensive surgical debridement of all (potentially) infected tissue, abdominal irrigation of liposomal amphotericin B and interferon gamma. Due to rapid diagnosis and intensive therapy the patient survived. |
| topic |
mucormycosis Renal transplant Interferon gamma Survival |
| url |
http://www.sciencedirect.com/science/article/pii/S2211753920300580 |
| work_keys_str_mv |
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