Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice

Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice

Abstract Background Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primordial germ cells travel to the genital ridge and st...

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Bibliographic Details
Main Authors: Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis, Leena Hilakivi-Clarke
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Transgenerational
n-6 Polyunsaturated fatty acids
Primordial germ cells
Maternal diet
Online Access:http://link.springer.com/article/10.1186/s13058-017-0866-x

Internet

http://link.springer.com/article/10.1186/s13058-017-0866-x

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