Application of a Physiologically Based Pharmacokinetic Model to Develop a Veterinary Amorphous Enrofloxacin Solid Dispersion

Application of a Physiologically Based Pharmacokinetic Model to Develop a Veterinary Amorphous Enrofloxacin Solid Dispersion

Zoonotic intestinal pathogens threaten human health and cause huge economic losses in farming. Enrofloxacin (ENR) shows high antibacterial activity against common intestinal bacteria. However, its poor palatability and low aqueous solubility limit the clinical application of ENR. To obtain an ENR or...

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Bibliographic Details
Main Authors: Kaixiang Zhou, Meixia Huo, Wenjin Ma, Kun Mi, Xiangyue Xu, Samah Attia Algharib, Shuyu Xie, Lingli Huang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
intestinal infections
enrofloxacin
solid dispersion
physiologically based pharmacokinetics model
formulation strategies
dose design
Online Access:https://www.mdpi.com/1999-4923/13/5/602

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