Strong selection during the last millennium for African ancestry in the admixed population of Madagascar

Strong selection during the last millennium for African ancestry in the admixed population of Madagascar

The population of Madagascar arose from admixture of Austronesian and Bantu genetic backgrounds. Analyzing local ancestry in genomes of 700 Malagasy, Pierron et al. identify signals of recent positive selection for African ancestry in a region on chromosome 1 with implications for physiology and dis...

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Main Authors: Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Veronica Pereda-loth, Jazmin Sanchez, Omar Alva, Amal Arachiche, Anne Boland, Robert Olaso, Jean-Francois Deleuze, Francois-Xavier Ricaut, Jean-Aimé Rakotoarisoa, Chantal Radimilahy, Mark Stoneking, Thierry Letellier
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03342-5
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spelling doaj-dbd4a41f1c95440fba742b905b02a21f2021-05-11T10:02:59ZengNature Publishing GroupNature Communications2041-17232018-03-01911910.1038/s41467-018-03342-5Strong selection during the last millennium for African ancestry in the admixed population of MadagascarDenis Pierron0Margit Heiske1Harilanto Razafindrazaka2Veronica Pereda-loth3Jazmin Sanchez4Omar Alva5Amal Arachiche6Anne Boland7Robert Olaso8Jean-Francois Deleuze9Francois-Xavier Ricaut10Jean-Aimé Rakotoarisoa11Chantal Radimilahy12Mark Stoneking13Thierry Letellier14Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseCommissariat à l’Energie Atomique, Institut Génomique, Centre National de GénotypageCommissariat à l’Energie Atomique, Institut Génomique, Centre National de GénotypageCommissariat à l’Energie Atomique, Institut Génomique, Centre National de GénotypageLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseInstitut de Civilisations/Musée d’Art et d’Archéologie, Université d’AntananarivoInstitut de Civilisations/Musée d’Art et d’Archéologie, Université d’AntananarivoDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary AnthropologyLaboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, UMR 5288 CNRS, Université de ToulouseThe population of Madagascar arose from admixture of Austronesian and Bantu genetic backgrounds. Analyzing local ancestry in genomes of 700 Malagasy, Pierron et al. identify signals of recent positive selection for African ancestry in a region on chromosome 1 with implications for physiology and disease risk.https://doi.org/10.1038/s41467-018-03342-5
collection DOAJ
language English
format Article
sources DOAJ
author Denis Pierron
Margit Heiske
Harilanto Razafindrazaka
Veronica Pereda-loth
Jazmin Sanchez
Omar Alva
Amal Arachiche
Anne Boland
Robert Olaso
Jean-Francois Deleuze
Francois-Xavier Ricaut
Jean-Aimé Rakotoarisoa
Chantal Radimilahy
Mark Stoneking
Thierry Letellier
spellingShingle Denis Pierron
Margit Heiske
Harilanto Razafindrazaka
Veronica Pereda-loth
Jazmin Sanchez
Omar Alva
Amal Arachiche
Anne Boland
Robert Olaso
Jean-Francois Deleuze
Francois-Xavier Ricaut
Jean-Aimé Rakotoarisoa
Chantal Radimilahy
Mark Stoneking
Thierry Letellier
Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
Nature Communications
author_facet Denis Pierron
Margit Heiske
Harilanto Razafindrazaka
Veronica Pereda-loth
Jazmin Sanchez
Omar Alva
Amal Arachiche
Anne Boland
Robert Olaso
Jean-Francois Deleuze
Francois-Xavier Ricaut
Jean-Aimé Rakotoarisoa
Chantal Radimilahy
Mark Stoneking
Thierry Letellier
author_sort Denis Pierron
title Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
title_short Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
title_full Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
title_fullStr Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
title_full_unstemmed Strong selection during the last millennium for African ancestry in the admixed population of Madagascar
title_sort strong selection during the last millennium for african ancestry in the admixed population of madagascar
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description The population of Madagascar arose from admixture of Austronesian and Bantu genetic backgrounds. Analyzing local ancestry in genomes of 700 Malagasy, Pierron et al. identify signals of recent positive selection for African ancestry in a region on chromosome 1 with implications for physiology and disease risk.
url https://doi.org/10.1038/s41467-018-03342-5
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