Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study

Background: Changes in reproductive hormones during menopause are associated with accumulation of intra-abdominal adipose tissue (IAAT), a subclinical indicator of cardiometabolic disease risk. Independent of reproductive hormones, unhealthy lifestyle contributes to IAAT gain. The Women in the South...

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Main Authors: Sheila A. Dugan, Brittney Lange-Maia, Kelly Karavolos, Rasa Kazlauskaite, Chiquia S. Hollings, Elizabeth Avery, Lisa Nackers, Elizabeth Lynch, Jennifer Ventrelle, Patricia Normand, Tricia Johnson, Francis Fullam, Karla Shipp-Johnson, JoEllen Wilbur, Lynda H. Powell
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Contemporary Clinical Trials Communications
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865416300291
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spelling doaj-dbd28cb0972844f293bc2327d80fe54e2020-11-24T22:46:09ZengElsevierContemporary Clinical Trials Communications2451-86542016-12-014C748310.1016/j.conctc.2016.07.002Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) studySheila A. Dugan0Brittney Lange-Maia1Kelly Karavolos2Rasa Kazlauskaite3Chiquia S. Hollings4Elizabeth Avery5Lisa Nackers6Elizabeth Lynch7Jennifer Ventrelle8Patricia Normand9Tricia Johnson10Francis Fullam11Karla Shipp-Johnson12JoEllen Wilbur13Lynda H. Powell14Department of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesSchool of Medicine and Public Health, University of Wisconsin-Madison, Madison WI, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesHealth Systems Management, Rush University Medical Center, Chicago, IL, United StatesStrategic Planning, Marketing and Program Development, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesCollege of Nursing, Rush University Medical Center, Chicago, IL, United StatesDepartment of Preventive Medicine, Rush University Medical Center, Chicago, IL, United StatesBackground: Changes in reproductive hormones during menopause are associated with accumulation of intra-abdominal adipose tissue (IAAT), a subclinical indicator of cardiometabolic disease risk. Independent of reproductive hormones, unhealthy lifestyle contributes to IAAT gain. The Women in the Southside Health and Fitness (WISHFIT) Study aims to develop a lifestyle approach to slowing IAAT accumulation as women begin the menopausal transition. Methods: The primary aim is to develop and conduct a proof-of-concept test of a multi-component, multi-level behavioral intervention targeting jointly physical activity, diet, and psychological well-being. Participants attend group sessions over 2 years to experiment with healthy living through both experiential and didactic learning, cultivate a health network, and draw on community resources to sustain change. The primary endpoint is 2-year IAAT progression, assessed using computerized tomography. Behavioral targets of treatment and secondary endpoints will be evaluated at 6, 12, 18 and 24 months. Change in social networks and community support will be assessed at 2 years. Results: WISHFIT recruited 71 pre- and peri-menopausal Caucasian and African American women (mean ± SD age = 47.6 ± 3.4 yrs; BMI = 33.6 ± 7.3 kg/m2; 52% African American). Baseline IAAT was 2104.1 ± 1201.3 cm3. IAAT, physical activity, BMI, and self-reported family income and resilience differed by ethnicity at baseline. Conclusions: WISHFIT is a multi-component, multi-level intervention aimed at producing a sustained improvement in physical activity, diet, and psychological well-being early in the menopausal transition to slow menopause-related accumulation of IAAT. It provides a model for the process of developing a behavioral treatment to manage a chronic disease.http://www.sciencedirect.com/science/article/pii/S2451865416300291Behavioral intervention developmentIntra-abdominal adipose tissueMenopauseHealthy livingMulti-level interventionPhysical activity
collection DOAJ
language English
format Article
sources DOAJ
author Sheila A. Dugan
Brittney Lange-Maia
Kelly Karavolos
Rasa Kazlauskaite
Chiquia S. Hollings
Elizabeth Avery
Lisa Nackers
Elizabeth Lynch
Jennifer Ventrelle
Patricia Normand
Tricia Johnson
Francis Fullam
Karla Shipp-Johnson
JoEllen Wilbur
Lynda H. Powell
spellingShingle Sheila A. Dugan
Brittney Lange-Maia
Kelly Karavolos
Rasa Kazlauskaite
Chiquia S. Hollings
Elizabeth Avery
Lisa Nackers
Elizabeth Lynch
Jennifer Ventrelle
Patricia Normand
Tricia Johnson
Francis Fullam
Karla Shipp-Johnson
JoEllen Wilbur
Lynda H. Powell
Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
Contemporary Clinical Trials Communications
Behavioral intervention development
Intra-abdominal adipose tissue
Menopause
Healthy living
Multi-level intervention
Physical activity
author_facet Sheila A. Dugan
Brittney Lange-Maia
Kelly Karavolos
Rasa Kazlauskaite
Chiquia S. Hollings
Elizabeth Avery
Lisa Nackers
Elizabeth Lynch
Jennifer Ventrelle
Patricia Normand
Tricia Johnson
Francis Fullam
Karla Shipp-Johnson
JoEllen Wilbur
Lynda H. Powell
author_sort Sheila A. Dugan
title Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
title_short Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
title_full Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
title_fullStr Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
title_full_unstemmed Design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: The Women in the Southside Health and Fitness (WISHFIT) study
title_sort design of a lifestyle intervention to slow menopause-related progression of intra-abdominal adipose tissue in women: the women in the southside health and fitness (wishfit) study
publisher Elsevier
series Contemporary Clinical Trials Communications
issn 2451-8654
publishDate 2016-12-01
description Background: Changes in reproductive hormones during menopause are associated with accumulation of intra-abdominal adipose tissue (IAAT), a subclinical indicator of cardiometabolic disease risk. Independent of reproductive hormones, unhealthy lifestyle contributes to IAAT gain. The Women in the Southside Health and Fitness (WISHFIT) Study aims to develop a lifestyle approach to slowing IAAT accumulation as women begin the menopausal transition. Methods: The primary aim is to develop and conduct a proof-of-concept test of a multi-component, multi-level behavioral intervention targeting jointly physical activity, diet, and psychological well-being. Participants attend group sessions over 2 years to experiment with healthy living through both experiential and didactic learning, cultivate a health network, and draw on community resources to sustain change. The primary endpoint is 2-year IAAT progression, assessed using computerized tomography. Behavioral targets of treatment and secondary endpoints will be evaluated at 6, 12, 18 and 24 months. Change in social networks and community support will be assessed at 2 years. Results: WISHFIT recruited 71 pre- and peri-menopausal Caucasian and African American women (mean ± SD age = 47.6 ± 3.4 yrs; BMI = 33.6 ± 7.3 kg/m2; 52% African American). Baseline IAAT was 2104.1 ± 1201.3 cm3. IAAT, physical activity, BMI, and self-reported family income and resilience differed by ethnicity at baseline. Conclusions: WISHFIT is a multi-component, multi-level intervention aimed at producing a sustained improvement in physical activity, diet, and psychological well-being early in the menopausal transition to slow menopause-related accumulation of IAAT. It provides a model for the process of developing a behavioral treatment to manage a chronic disease.
topic Behavioral intervention development
Intra-abdominal adipose tissue
Menopause
Healthy living
Multi-level intervention
Physical activity
url http://www.sciencedirect.com/science/article/pii/S2451865416300291
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