Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient

We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonst...

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Main Authors: Jun Ma, Ruiyun Guo, Yongzhou Song, Jing Zhang, Baofeng Feng, Asiamah Ernest Amponsah, Desheng Kong, Jingjing He, Wei Zhang, Aijing Liu, Lin Wei, Sanbing Shen, Timothy O'Brien, Huixian Cui
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506119300479
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spelling doaj-dbc0d29372a54cd3a79653a1798251d62020-11-25T02:46:33ZengElsevierStem Cell Research1873-50612019-04-0136Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patientJun Ma0Ruiyun Guo1Yongzhou Song2Jing Zhang3Baofeng Feng4Asiamah Ernest Amponsah5Desheng Kong6Jingjing He7Wei Zhang8Aijing Liu9Lin Wei10Sanbing Shen11Timothy O'Brien12Huixian Cui13Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Second Affiliated Hospital of Hebei Medical University, ChinaThe Fourth Hospital of Shijiazhuang, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Second Affiliated Hospital of Hebei Medical University, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Regenerative Medicine Institute, National University of Ireland Galway, Galway, IrelandHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Regenerative Medicine Institute, National University of Ireland Galway, Galway, IrelandHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.http://www.sciencedirect.com/science/article/pii/S1873506119300479
collection DOAJ
language English
format Article
sources DOAJ
author Jun Ma
Ruiyun Guo
Yongzhou Song
Jing Zhang
Baofeng Feng
Asiamah Ernest Amponsah
Desheng Kong
Jingjing He
Wei Zhang
Aijing Liu
Lin Wei
Sanbing Shen
Timothy O'Brien
Huixian Cui
spellingShingle Jun Ma
Ruiyun Guo
Yongzhou Song
Jing Zhang
Baofeng Feng
Asiamah Ernest Amponsah
Desheng Kong
Jingjing He
Wei Zhang
Aijing Liu
Lin Wei
Sanbing Shen
Timothy O'Brien
Huixian Cui
Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
Stem Cell Research
author_facet Jun Ma
Ruiyun Guo
Yongzhou Song
Jing Zhang
Baofeng Feng
Asiamah Ernest Amponsah
Desheng Kong
Jingjing He
Wei Zhang
Aijing Liu
Lin Wei
Sanbing Shen
Timothy O'Brien
Huixian Cui
author_sort Jun Ma
title Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
title_short Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
title_full Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
title_fullStr Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
title_full_unstemmed Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient
title_sort generation and characterization of a human induced pluripotent stem cell (ipsc) line (hebhmui001-a) from a sporadic parkinson's disease patient
publisher Elsevier
series Stem Cell Research
issn 1873-5061
publishDate 2019-04-01
description We generated a human induced pluripotent stem cell (iPSC) line from the skin fibroblasts of a 62-year-old female patient clinically diagnosed with sporadic Parkinson's disease (PD). The generated iPSCs maintained their normal karyotype, expressed pluripotency stem cell markers, and were demonstrated to be capable of differentiating into cells representative of the three embryonic germ layers. The generated line could be used for PD modeling in order to understand the mechanisms that influence the disorder.
url http://www.sciencedirect.com/science/article/pii/S1873506119300479
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