Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

The role of reactive oxygen species (ROS) in signalling and specific targets is not fully understood. Here the authors perform a global proteomic analysis to delineate the yeast redoxome and show that increased levels of intracellular ROS caused by dysfunctional mitochondria decrease global protein...

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Main Authors:	Ulrike Topf, Ida Suppanz, Lukasz Samluk, Lidia Wrobel, Alexander Böser, Paulina Sakowska, Bettina Knapp, Martyna K. Pietrzyk, Agnieszka Chacinska, Bettina Warscheid
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02694-8

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spelling	doaj-dbae8e44a79e41df9b1f9b615b6f89012021-05-11T09:53:56ZengNature Publishing GroupNature Communications2041-17232018-01-019111710.1038/s41467-017-02694-8Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen speciesUlrike Topf0Ida Suppanz1Lukasz Samluk2Lidia Wrobel3Alexander Böser4Paulina Sakowska5Bettina Knapp6Martyna K. Pietrzyk7Agnieszka Chacinska8Bettina Warscheid9International Institute of Molecular and Cell BiologyFaculty of Biology, Institute of Biology II, Biochemistry–Functional Proteomics, University of FreiburgInternational Institute of Molecular and Cell BiologyInternational Institute of Molecular and Cell BiologyFaculty of Biology, Institute of Biology II, Biochemistry–Functional Proteomics, University of FreiburgInternational Institute of Molecular and Cell BiologyFaculty of Biology, Institute of Biology II, Biochemistry–Functional Proteomics, University of FreiburgInternational Institute of Molecular and Cell BiologyInternational Institute of Molecular and Cell BiologyFaculty of Biology, Institute of Biology II, Biochemistry–Functional Proteomics, University of FreiburgThe role of reactive oxygen species (ROS) in signalling and specific targets is not fully understood. Here the authors perform a global proteomic analysis to delineate the yeast redoxome and show that increased levels of intracellular ROS caused by dysfunctional mitochondria decrease global protein synthesis.https://doi.org/10.1038/s41467-017-02694-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ulrike Topf Ida Suppanz Lukasz Samluk Lidia Wrobel Alexander Böser Paulina Sakowska Bettina Knapp Martyna K. Pietrzyk Agnieszka Chacinska Bettina Warscheid
spellingShingle	Ulrike Topf Ida Suppanz Lukasz Samluk Lidia Wrobel Alexander Böser Paulina Sakowska Bettina Knapp Martyna K. Pietrzyk Agnieszka Chacinska Bettina Warscheid Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species Nature Communications
author_facet	Ulrike Topf Ida Suppanz Lukasz Samluk Lidia Wrobel Alexander Böser Paulina Sakowska Bettina Knapp Martyna K. Pietrzyk Agnieszka Chacinska Bettina Warscheid
author_sort	Ulrike Topf
title	Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
title_short	Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
title_full	Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
title_fullStr	Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
title_full_unstemmed	Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
title_sort	quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	The role of reactive oxygen species (ROS) in signalling and specific targets is not fully understood. Here the authors perform a global proteomic analysis to delineate the yeast redoxome and show that increased levels of intracellular ROS caused by dysfunctional mitochondria decrease global protein synthesis.
url	https://doi.org/10.1038/s41467-017-02694-8
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Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

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