The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of Human Conjunctival Fibroblasts via the PI3K/Akt Signaling Pathway

The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of Human Conjunctival Fibroblasts via the PI3K/Akt Signaling Pathway

Recent evidence suggests that chloride channels are critical for cell proliferation, migration, and differentiation. We examined the effects of transforming growth factor (TGF)-β1 on chloride channel expression and associations with human conjunctival fibroblast (HConF) biology. To investigate the p...

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Bibliographic Details
Main Authors: Lixia Sun, Yaru Dong, Jing Zhao, Yuan Yin, Yajuan Zheng
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:International Journal of Molecular Sciences
Subjects:
CLC-2 siRNA
TGF-β1 differentiation
extracellular matrix
human conjunctival fibroblasts
migration
signaling pathway
Online Access:http://www.mdpi.com/1422-0067/17/6/910

Internet

http://www.mdpi.com/1422-0067/17/6/910

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