CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)

The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactio...

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Main Authors:	V. A. Lyodov, P. G. Aparin
Format:	Article
Language:	Russian
Published:	Scientific Сentre for Family Health and Human Reproduction Problems 2014-07-01
Series:	Acta Biomedica Scientifica
Subjects:	shigella flexneri 2а flexner dysentery shigella flexneri 2a shigellosis s. flexneri 2a vaccines
Online Access:	https://www.actabiomedica.ru/jour/article/view/1797

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spelling	doaj-db91a2dac1da4b1db35df80eb65dcba72021-08-17T13:52:50ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962014-07-010491951743CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)V. A. Lyodov0P. G. Aparin1National Research Center “Institute of Immunology” of Federal Medical-Biological Agency of RussiaNational Research Center “Institute of Immunology” of Federal Medical-Biological Agency of RussiaThe article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactions showed good acceptability and low reactogenicity of candidate vaccine "FLEXVAC®" in the doses from 25 to 100 gg. In the majority ofvolunteers immunized by the candidate vaccine "FLEXVAC®" we registered 4 and more times seroconversion of IgG and IgA classes antibodies playing basic role in the formation of adaptive anti-shigella immune response.https://www.actabiomedica.ru/jour/article/view/1797shigella flexneri 2аflexner dysenteryshigella flexneri 2ashigellosiss. flexneri 2a vaccines
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	V. A. Lyodov P. G. Aparin
spellingShingle	V. A. Lyodov P. G. Aparin CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS) Acta Biomedica Scientifica shigella flexneri 2а flexner dysentery shigella flexneri 2a shigellosis s. flexneri 2a vaccines
author_facet	V. A. Lyodov P. G. Aparin
author_sort	V. A. Lyodov
title	CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
title_short	CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
title_full	CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
title_fullStr	CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
title_full_unstemmed	CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)
title_sort	clinical studies of the vaccine preparation for prevention of flexner dysentery on the basis of modified shigella flexneri lipopolysaccharide (based on the results of the i phase of clinical trials)
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
series	Acta Biomedica Scientifica
issn	2541-9420 2587-9596
publishDate	2014-07-01
description	The article presents the results of the I phase of clinical trials of a vaccine preparationfor prevention of Flexner dysentery on the basis of modified Shigella flexneri lipopolysaccharide on the limited contingent of adult volunteers (26 persons). Studying general and local post-inoculative reactions showed good acceptability and low reactogenicity of candidate vaccine "FLEXVAC®" in the doses from 25 to 100 gg. In the majority ofvolunteers immunized by the candidate vaccine "FLEXVAC®" we registered 4 and more times seroconversion of IgG and IgA classes antibodies playing basic role in the formation of adaptive anti-shigella immune response.
topic	shigella flexneri 2а flexner dysentery shigella flexneri 2a shigellosis s. flexneri 2a vaccines
url	https://www.actabiomedica.ru/jour/article/view/1797
work_keys_str_mv	AT valyodov clinicalstudiesofthevaccinepreparationforpreventionofflexnerdysenteryonthebasisofmodifiedshigellaflexnerilipopolysaccharidebasedontheresultsoftheiphaseofclinicaltrials AT pgaparin clinicalstudiesofthevaccinepreparationforpreventionofflexnerdysenteryonthebasisofmodifiedshigellaflexnerilipopolysaccharidebasedontheresultsoftheiphaseofclinicaltrials
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CLINICAL STUDIES OF THE VACCINE PREPARATION FOR PREVENTION OF FLEXNER DYSENTERY ON THE BASIS OF MODIFIED SHIGELLA FLEXNERI LIPOPOLYSACCHARIDE (BASED ON THE RESULTS OF THE I PHASE OF CLINICAL TRIALS)

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