The Life-Cycle of the HIV-1 Gag–RNA Complex

The Life-Cycle of the HIV-1 Gag–RNA Complex

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA...

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Bibliographic Details
Main Authors: Elodie Mailler, Serena Bernacchi, Roland Marquet, Jean-Christophe Paillart, Valérie Vivet-Boudou, Redmond P. Smyth
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Viruses
Subjects:
HIV-1
packaging
Gag
genomic RNA
assembly
Online Access:http://www.mdpi.com/1999-4915/8/9/248
Description
Summary:Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55Gag precursor polyprotein, and the processes leading to its incorporation into viral particles.
ISSN:1999-4915

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