Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals,...

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Bibliographic Details
Main Authors: Matilde Colella, Andrea Gerbino, Aldebaran M. Hofer, Silvana Curci
Format: Article
Language:English
Published: F1000 Research Ltd 2016-10-01
Series:F1000Research
Subjects:
Cell Signaling
Cell Signaling & Trafficking Structures
Drug Discovery & Design
Endocrine & Metabolic Pharmacology
Membranes & Sorting
Molecular Pharmacology
Online Access:https://f1000research.com/articles/5-2535/v1
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spelling doaj-db8cfbf6c6bd4efe9b6098b6bd3ff7392020-11-25T02:53:51ZengF1000 Research LtdF1000Research2046-14022016-10-01510.12688/f1000research.8963.19643Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]Matilde Colella0Andrea Gerbino1Aldebaran M. Hofer2Silvana Curci3Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari , Bari, ItalyDepartment of Biosciences, Biotechnology and Biopharmaceutics, University of Bari , Bari, ItalyDepartment of Surgery, Brigham & Women’s Hospital, Harvard Medical School and VA Boston Healthcare System, West Roxbury, MA, USADepartment of Surgery, Brigham & Women’s Hospital, Harvard Medical School and VA Boston Healthcare System, West Roxbury, MA, USAThe extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.https://f1000research.com/articles/5-2535/v1Cell SignalingCell Signaling & Trafficking StructuresDrug Discovery & DesignEndocrine & Metabolic PharmacologyMembranes & SortingMolecular Pharmacology
collection DOAJ
language English
format Article
sources DOAJ
author Matilde Colella
Andrea Gerbino
Aldebaran M. Hofer
Silvana Curci
spellingShingle Matilde Colella
Andrea Gerbino
Aldebaran M. Hofer
Silvana Curci
Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
F1000Research
Cell Signaling
Cell Signaling & Trafficking Structures
Drug Discovery & Design
Endocrine & Metabolic Pharmacology
Membranes & Sorting
Molecular Pharmacology
author_facet Matilde Colella
Andrea Gerbino
Aldebaran M. Hofer
Silvana Curci
author_sort Matilde Colella
title Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
title_short Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
title_full Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
title_fullStr Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
title_full_unstemmed Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
title_sort recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2016-10-01
description The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.
topic Cell Signaling
Cell Signaling & Trafficking Structures
Drug Discovery & Design
Endocrine & Metabolic Pharmacology
Membranes & Sorting
Molecular Pharmacology
url https://f1000research.com/articles/5-2535/v1
work_keys_str_mv AT matildecolella recentadvancesinunderstandingtheextracellularcalciumsensingreceptorversion1referees3approved
AT andreagerbino recentadvancesinunderstandingtheextracellularcalciumsensingreceptorversion1referees3approved
AT aldebaranmhofer recentadvancesinunderstandingtheextracellularcalciumsensingreceptorversion1referees3approved
AT silvanacurci recentadvancesinunderstandingtheextracellularcalciumsensingreceptorversion1referees3approved
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