Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

Recent advances in understanding the extracellular calcium-sensing receptor [version 1; referees: 3 approved]

The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals,...

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Bibliographic Details
Main Authors: Matilde Colella, Andrea Gerbino, Aldebaran M. Hofer, Silvana Curci
Format: Article
Language:English
Published: F1000 Research Ltd 2016-10-01
Series:F1000Research
Subjects:
Cell Signaling
Cell Signaling & Trafficking Structures
Drug Discovery & Design
Endocrine & Metabolic Pharmacology
Membranes & Sorting
Molecular Pharmacology
Online Access:https://f1000research.com/articles/5-2535/v1
Description
Summary:The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.
ISSN:2046-1402

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