A retrospective comparison of concurrent bolus 5-fluorouracil or raltitrexed in preoperative chemoradiation for locally advanced rectal cancer

BACKGROUND: 5-fluorouracil (FU) is commonly used in preoperative chemoradiation in locally advanced rectal cancer, but not all patients cooperate in taking the 5-day continuous infusion regimen. Raltitrexed (RA), a thymidylate synthase inhibitor, is one of the agents used in place of FU in such case...

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Bibliographic Details
Main Authors: Adnan Yoney, Bulent Askaroglu, Tayfun Hancilar, Levent Isikli, Mustafa Unsal
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387608500574