Cutaneous vasculitis and granulomatous hepatitis as paradoxical adverse events of Infliximab

Cutaneous vasculitis and granulomatous hepatitis as paradoxical adverse events of Infliximab

Biological agents revolutionised the treatment of inflammatory arthropathies. Paradoxical adverse events (PAEs) are rare immunological side effects caused by such agents. The authors report concurrent presentation of two rare PAEs of tumor-necrosis-factor alpha inhibitors (iTNFa) – cutaneous vasculi...

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Bibliographic Details
Main Authors: DIogo Esperança Almeida, Emanuel Costa, Joana Sousa Neves, Marcos Cerqueira, Ana Roxo Ribeiro
Format: Article
Language:English
Published: Sociedade Portuguesa de Reumatologia 2020-04-01
Series:Acta Reumatológica Portuguesa
Subjects:
psoriatic arthritis
paradoxical adverse events
anti-tnf drugs
Online Access:http://www.actareumatologica.pt/files/article/1309_cutaneous_vasculitis_and_granulomatous_hepatitis_as_paradoxical_adverse_events_of_infliximab_file.pdf
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Summary:Biological agents revolutionised the treatment of inflammatory arthropathies. Paradoxical adverse events (PAEs) are rare immunological side effects caused by such agents. The authors report concurrent presentation of two rare PAEs of tumor-necrosis-factor alpha inhibitors (iTNFa) – cutaneous vasculitis and granulomatous hepatitis – in a patient with psoriatic arthritis treated with infliximab and briefly discuss aspects of diagnosis, pathophysiology and management of such events in light of the available evidence.
ISSN:0303-464X

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