Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation

Transcriptional activation of CBFβ by CDK11p110 is necessary to promote osteosarcoma cell proliferation

Abstract Background Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 transcriptionally regulated genes are largely unknown. Methods In this s...

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Bibliographic Details
Main Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek, Zhenfeng Duan
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cell Communication and Signaling
Subjects:
CDK11
CBFβ
Osteosarcoma
Transcription
Online Access:http://link.springer.com/article/10.1186/s12964-019-0440-5

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http://link.springer.com/article/10.1186/s12964-019-0440-5

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