High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

Metastatic uveal melanoma (UM) is a rare, but often lethal, form of ocular cancer arising from melanocytes within the uveal tract. UM has a high propensity to spread hematogenously to the liver, with up to 50% of patients developing liver metastases. Unfortunately, once liver metastasis occurs, pati...

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Bibliographic Details
Main Authors: Kayleigh Slater, Aisling B. Heeran, Sandra Garcia-Mulero, Helen Kalirai, Rebeca Sanz-Pamplona, Arman Rahman, Nebras Al-Attar, Mays Helmi, Fiona O’Connell, Rosa Bosch, Anna Portela, Alberto Villanueva, William M. Gallagher, Lasse D. Jensen, Josep M. Piulats, Sarah E. Coupland, Jacintha O’Sullivan, Breandán N. Kennedy
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
uveal melanoma
cysteinyl leukotriene receptors
patient survival
G protein-coupled receptors
angiogenesis
inflammation
Online Access:https://www.mdpi.com/2072-6694/12/10/2950

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