Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production

Obese Mice with Dyslipidemia Exhibit Meibomian Gland Hypertrophy and Alterations in Meibum Composition and Aqueous Tear Production

Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) change in a mouse model of diet-induced obesity whe...

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Bibliographic Details
Main Authors: Eugene A. Osae, Tiffany Bullock, Madhavi Chintapalati, Susanne Brodesser, Samuel Hanlon, Rachel Redfern, Philipp Steven, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
obesity
dyslipidemia
meibum
lipids
meibomian gland dysfunction
dry eye
Online Access:https://www.mdpi.com/1422-0067/21/22/8772

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