A case report of langerhans, Histiocytosis following Hodgkin lymphoma

• Main Authors: Azar naimi, Nahid Raeesi Raeesi, Parvin Rajabi, Mitra Heidarpour, Majid Heidarpour, Abasgholi Amini
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2010-01-01
• Series: Journal of Research in Medical Sciences
• Subjects: Hodgkin lymphoma, Langerhans histiocytosis, Immunohistochemistry
• Online Access: http://journals.mui.ac.ir/jrms/article/view/1455
• ISSN: 1735-1995; 1735-7136

<span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt">The occurrence of Langerhans Histiocytosis in a patient with lymphoma </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt">is<span>  </span>an indication of complex relationship between these two diseases.</span><span style="font-size: 14pt"><span>  </span></span><span style="font-size: 14pt"><span> </span></span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt"><span>  </span>These<span>  </span>two conditions have similarities clinically and </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"><span>   </span>histopathologically<span>  </span>therefore. </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">Considering probability of concurrent occurrence of these disease and </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">methods used to differentiated between them, are important in preventing </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">misdiagnosis. These diseases are far apart regarding their treatment </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">and prognosis. Immunohistochemical staining (IHC) is one of the most </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">important aids in differential diagnosis. </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">The probable etiology of these diseases, consistency concurrent </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">occurrence of them is an open area for more research. <span> </span></span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt">In this article, a 9 year old child is reported that 3 years after diagnosis <span> </span></span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt">treatment of mixed cellularity Hodgkin lymphoma, was afflicted with</span><span style="font-size: 14pt"> </span><span style="font-size: 14pt">and </span><span style="font-size: 14pt"><span>    </span></span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">langerhans Histiocytosis .</span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;">Concurrent occurrence of these two conditions in the same patient, </span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span><span style="font-family: Times New Roman;"><span style="font-size: 14pt">particularly when they are not simultaneous, is rare.</span><span style="font-size: 14pt"><span>  </span></span></span><span style="font-size: 14pt"><span style="font-family: Times New Roman;"> </span></span>