Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase

Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase

Survival rates of children with acute lymphoblastic leukemia have improved since the incorporation of asparaginase in the treatment protocol, but the medication has potential serious complications, including vascular thrombosis. Here, we describe the case of a 13-year-old boy with pre-T-cell acute l...

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Main Authors: Elizabeth R. Tang, MD, Teresa Chapman, MD, MA, Laura S. Finn, MD, Kasey J. Leger, MD, MSc
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Radiology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043318300700
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spelling doaj-db6b4aa677274d52807c9e001abc14252020-11-24T23:08:01ZengElsevierRadiology Case Reports1930-04332018-06-01133568572Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargaseElizabeth R. Tang, MD0Teresa Chapman, MD, MA1Laura S. Finn, MD2Kasey J. Leger, MD, MSc3Department of Radiology, Seattle Children's Hospital, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, USADepartment of Radiology, Seattle Children's Hospital, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, USA; Corresponding author.Department of Pathology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USADepartment of Pediatrics, Division of Hematology-Oncology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USASurvival rates of children with acute lymphoblastic leukemia have improved since the incorporation of asparaginase in the treatment protocol, but the medication has potential serious complications, including vascular thrombosis. Here, we describe the case of a 13-year-old boy with pre-T-cell acute lymphoblastic leukemia whose treatment course was complicated by perforated jejunitis requiring resection of a portion of his small bowel. Pathologic assessment showed transmural ischemia, mesenteric venous and arterial thrombi, and scattered cytomegalovirus inclusion bodies. Pediatric mesenteric ischemia is rare, and its consideration in patients treated with asparaginase is discussed. Keywords: Acute lymphoblastic leukemia, Pediatric, Asparaginase, Complications, Acute mesenteric ischemia, Computed tomographyhttp://www.sciencedirect.com/science/article/pii/S1930043318300700
collection DOAJ
language English
format Article
sources DOAJ
author Elizabeth R. Tang, MD
Teresa Chapman, MD, MA
Laura S. Finn, MD
Kasey J. Leger, MD, MSc
spellingShingle Elizabeth R. Tang, MD
Teresa Chapman, MD, MA
Laura S. Finn, MD
Kasey J. Leger, MD, MSc
Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
Radiology Case Reports
author_facet Elizabeth R. Tang, MD
Teresa Chapman, MD, MA
Laura S. Finn, MD
Kasey J. Leger, MD, MSc
author_sort Elizabeth R. Tang, MD
title Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
title_short Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
title_full Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
title_fullStr Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
title_full_unstemmed Perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
title_sort perforated jejunitis in a child with acute lymphoblastic leukemia treated with pegaspargase
publisher Elsevier
series Radiology Case Reports
issn 1930-0433
publishDate 2018-06-01
description Survival rates of children with acute lymphoblastic leukemia have improved since the incorporation of asparaginase in the treatment protocol, but the medication has potential serious complications, including vascular thrombosis. Here, we describe the case of a 13-year-old boy with pre-T-cell acute lymphoblastic leukemia whose treatment course was complicated by perforated jejunitis requiring resection of a portion of his small bowel. Pathologic assessment showed transmural ischemia, mesenteric venous and arterial thrombi, and scattered cytomegalovirus inclusion bodies. Pediatric mesenteric ischemia is rare, and its consideration in patients treated with asparaginase is discussed. Keywords: Acute lymphoblastic leukemia, Pediatric, Asparaginase, Complications, Acute mesenteric ischemia, Computed tomography
url http://www.sciencedirect.com/science/article/pii/S1930043318300700
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