Coincident Activation of Glutamate Receptors Enhances GABAA Receptor-Induced Ionic Plasticity of the Intracellular Cl−-Concentration in Dissociated Neuronal Cultures

Coincident Activation of Glutamate Receptors Enhances GABAA Receptor-Induced Ionic Plasticity of the Intracellular Cl−-Concentration in Dissociated Neuronal Cultures

Massive activation of γ-amino butyric acid A (GABAA) receptors during pathophysiological activity induces an increase in the intracellular Cl−-concentration ([Cl−]i), which is sufficient to render GABAergic responses excitatory. However, to what extent physiological levels of GABAergic activity can...

Full description

Bibliographic Details
Main Authors: Lisa Halbhuber, Cécilia Achtner, Heiko J. Luhmann, Anne Sinning, Werner Kilb
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cl−-homeostasis
KCC2
reversal potential
rheobase
ionic plasticity
GABA(A) receptors
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00497/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00497/full

Similar Items