HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease

Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mu...

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Main Authors: Daniel Tarade, Claire M. Robinson, Jeffrey E. Lee, Michael Ohh
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05554-1
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spelling doaj-db4f15857e80480b8d26763e42ee28942021-05-11T09:57:51ZengNature Publishing GroupNature Communications2041-17232018-08-019111110.1038/s41467-018-05554-1HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven diseaseDaniel Tarade0Claire M. Robinson1Jeffrey E. Lee2Michael Ohh3Department of Laboratory Medicine & Pathobiology, University of TorontoDepartment of Laboratory Medicine & Pathobiology, University of TorontoDepartment of Laboratory Medicine & Pathobiology, University of TorontoDepartment of Laboratory Medicine & Pathobiology, University of TorontoHypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.https://doi.org/10.1038/s41467-018-05554-1
collection DOAJ
language English
format Article
sources DOAJ
author Daniel Tarade
Claire M. Robinson
Jeffrey E. Lee
Michael Ohh
spellingShingle Daniel Tarade
Claire M. Robinson
Jeffrey E. Lee
Michael Ohh
HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
Nature Communications
author_facet Daniel Tarade
Claire M. Robinson
Jeffrey E. Lee
Michael Ohh
author_sort Daniel Tarade
title HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_short HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_full HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_fullStr HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_full_unstemmed HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
title_sort hif-2α-pvhl complex reveals broad genotype-phenotype correlations in hif-2α-driven disease
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Hypoxia inducible factor (HIF)-2α transcription factor is mutated in polycythemia and various neuroendocrine tumors. Here the authors present the crystal structure of a HIF-2α peptide bound to the pVHL-elongin B-elongin C (VBC) heterotrimeric complex and propose a classification scheme for HIF-2α mutations that helps to predict disease phenotype outcome.
url https://doi.org/10.1038/s41467-018-05554-1
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AT jeffreyelee hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease
AT michaelohh hif2apvhlcomplexrevealsbroadgenotypephenotypecorrelationsinhif2adrivendisease
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